000165274 001__ 165274
000165274 005__ 20251219174252.0
000165274 0247_ $$2doi$$a10.1016/j.physbeh.2025.115189
000165274 0248_ $$2sideral$$a146716
000165274 037__ $$aART-2026-146716
000165274 041__ $$aeng
000165274 100__ $$aMartínez-Caballero, M.A.
000165274 245__ $$aKetamine attenuates the effects of intermittent social defeat on anxiety, social interaction and cocaine-induced conditioned place preference in male mice
000165274 260__ $$c2026
000165274 5060_ $$aAccess copy available to the general public$$fUnrestricted
000165274 5203_ $$aMice exposed to intermittent social defeat (ISD) stress in late adolescence exhibit short-term anxiety- and depression-like behaviours and demonstrate greater sensitivity to the rewarding effects of cocaine in adulthood. Furthermore, the development of depression-like symptoms predicts subsequent enhanced vulnerability to cocaine reward. The aim of this study was to investigate whether ketamine, a non-competitive glutamate N-methyl-D-aspartate (NMDA) receptor antagonist with antidepressant properties, could prevent the short-term effects of ISD on anxiety- and depression-like behaviours and the long-term effects of ISD on the cocaine-induced conditioned place preference. Four groups of late adolescent C57BL/6 male mice were used. One non-stressed group (control) and three ISD-exposed groups treated with ketamine (0, 10 or 30 mg/kg). After the last defeat episode, the mice were tested in the elevated plus maze, social interaction, splash and tail suspension tests. Three weeks later, the mice were conditioned with cocaine (1 mg/kg). Stressed mice showed anxiety, displayed a deficit in social interaction, spent less time immobile in the tail suspension test and developed a cocaine place preference. Ketamine attenuated ISD-induced anxiety, social avoidance and cocaine reward potentiation. These results support the usefulness of ketamine in preventing some effects of social stress.
000165274 536__ $$9info:eu-repo/grantAgreement/ES/MICINN/PID2020-118945RB-I00
000165274 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
000165274 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000165274 700__ $$aGarcía-Pardo, M.P.$$uUniversidad de Zaragoza
000165274 700__ $$aCalpe-López, C.
000165274 700__ $$aArenas, M.C
000165274 700__ $$aManzanedo, C
000165274 700__ $$aAguilar, M.A.
000165274 7102_ $$14009$$2735$$aUniversidad de Zaragoza$$bDpto. Psicología y Sociología$$cÁrea Psicolog.Evolut.Educac
000165274 773__ $$g305 (2026), 115189 [8 pp.]$$pPhysiol. behav.$$tPhysiology and Behavior$$x0031-9384
000165274 8564_ $$s1213412$$uhttps://zaguan.unizar.es/record/165274/files/texto_completo.pdf$$yVersión publicada
000165274 8564_ $$s2485155$$uhttps://zaguan.unizar.es/record/165274/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000165274 909CO $$ooai:zaguan.unizar.es:165274$$particulos$$pdriver
000165274 951__ $$a2025-12-19-14:44:12
000165274 980__ $$aARTICLE