000165363 001__ 165363
000165363 005__ 20260107201858.0
000165363 0247_ $$2doi$$a10.3390/ani16010017
000165363 0248_ $$2sideral$$a147059
000165363 037__ $$aART-2026-147059
000165363 041__ $$aeng
000165363 100__ $$0(orcid)0000-0002-0313-5926$$aOrtín, Aurora$$uUniversidad de Zaragoza
000165363 245__ $$aThe treatment of contagious ecthyma in lambs with a local anaesthetic/antiseptic wound formulation lowers serum amyloid a responses
000165363 260__ $$c2026
000165363 5060_ $$aAccess copy available to the general public$$fUnrestricted
000165363 5203_ $$aContagious ecthyma (CE) is a widespread, highly contagious zoonotic skin disease of small ruminants caused by the Orf virus (ORFV), leading to substantial economic losses and welfare concerns. There is no specific treatment, with topical antiseptics and oral or parenteral antibiotics often administered for preventing secondary infections, risking antimicrobial resistance. This study assessed the effect of treating CE in lambs with an antibiotic-free topical anaesthetic/antiseptic formulation (Tri-Solfen®; T-S; Medical Ethics, Australia/MultiSolfen®; M-S; Dechra, UK). Serum amyloid A (SAA), a marker of systemic inflammation, was measured in both experimentally and naturally infected lambs allocated to treated and untreated groups. Samples were collected prior to (T0) and at 2 (T2), 7 (T7) and 14 (T14) days post-treatment in experimentally infected lambs and at T0, 10 (T10) and 20 (T20) days post-treatment in naturally affected lambs. In the experimental infection, SAA concentrations were lower in the treated group than in controls at T7 and significantly lower at T14. In the natural outbreak, SAA concentrations significantly decreased over time in the treated group, with a consistent trend toward lower values than in controls. These findings indicate that this therapeutic formulation reduces systemic inflammatory responses in lambs affected by CE, supporting its use as an alternative to antibiotics.
000165363 536__ $$9info:eu-repo/grantAgreement/ES/DGA/A15-20R$$9info:eu-repo/grantAgreement/ES/DGA/A15-23R
000165363 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es
000165363 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000165363 700__ $$0(orcid)0000-0001-6209-4282$$aVillanueva-Saz, Sergio$$uUniversidad de Zaragoza
000165363 700__ $$0(orcid)0000-0002-7822-6646$$aLacasta, Delia$$uUniversidad de Zaragoza
000165363 700__ $$aWindsor, Peter Andrew
000165363 700__ $$0(orcid)0000-0002-2557-4890$$aFernández, Antonio$$uUniversidad de Zaragoza
000165363 700__ $$0(orcid)0009-0003-9757-3840$$aQuilez, Pablo$$uUniversidad de Zaragoza
000165363 700__ $$0(orcid)0000-0002-8474-2831$$aRuiz, Hector
000165363 700__ $$0(orcid)0000-0002-9723-9004$$aGómez, Alex
000165363 700__ $$aGuallar, David
000165363 700__ $$0(orcid)0000-0002-7655-2472$$aRuiz de Arcaute, Marta$$uUniversidad de Zaragoza
000165363 7102_ $$11009$$2617$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Medicina y Cirugía Animal
000165363 773__ $$g16, 1 (2026), 17 [12 pp.]$$pAnimals (Basel)$$tAnimals$$x2076-2615
000165363 8564_ $$s555246$$uhttps://zaguan.unizar.es/record/165363/files/texto_completo.pdf$$yVersión publicada
000165363 8564_ $$s2525499$$uhttps://zaguan.unizar.es/record/165363/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000165363 909CO $$ooai:zaguan.unizar.es:165363$$particulos$$pdriver
000165363 951__ $$a2026-01-07-18:53:11
000165363 980__ $$aARTICLE