165363 20260318135944.0 doi 10.3390/ani16010017 sideral 147059 ART-2026-147059 eng Ortín, Aurora Universidad de Zaragoza (orcid)0000-0002-0313-5926 The treatment of contagious ecthyma in lambs with a local anaesthetic/antiseptic wound formulation lowers serum amyloid a responses 2026 Access copy available to the general public Unrestricted Contagious ecthyma (CE) is a widespread, highly contagious zoonotic skin disease of small ruminants caused by the Orf virus (ORFV), leading to substantial economic losses and welfare concerns. There is no specific treatment, with topical antiseptics and oral or parenteral antibiotics often administered for preventing secondary infections, risking antimicrobial resistance. This study assessed the effect of treating CE in lambs with an antibiotic-free topical anaesthetic/antiseptic formulation (Tri-Solfen®; T-S; Medical Ethics, Australia/MultiSolfen®; M-S; Dechra, UK). Serum amyloid A (SAA), a marker of systemic inflammation, was measured in both experimentally and naturally infected lambs allocated to treated and untreated groups. Samples were collected prior to (T0) and at 2 (T2), 7 (T7) and 14 (T14) days post-treatment in experimentally infected lambs and at T0, 10 (T10) and 20 (T20) days post-treatment in naturally affected lambs. In the experimental infection, SAA concentrations were lower in the treated group than in controls at T7 and significantly lower at T14. In the natural outbreak, SAA concentrations significantly decreased over time in the treated group, with a consistent trend toward lower values than in controls. These findings indicate that this therapeutic formulation reduces systemic inflammatory responses in lambs affected by CE, supporting its use as an alternative to antibiotics. info:eu-repo/grantAgreement/ES/DGA/A15-20R info:eu-repo/grantAgreement/ES/DGA/A15-23R info:eu-repo/semantics/openAccess by https://creativecommons.org/licenses/by/4.0/deed.es info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Villanueva-Saz, Sergio Universidad de Zaragoza (orcid)0000-0001-6209-4282 Lacasta, Delia Universidad de Zaragoza (orcid)0000-0002-7822-6646 Windsor, Peter Andrew Fernández, Antonio Universidad de Zaragoza (orcid)0000-0002-2557-4890 Quilez, Pablo Universidad de Zaragoza (orcid)0009-0003-9757-3840 Ruiz, Hector Universidad de Zaragoza (orcid)0000-0002-8474-2831 Gómez, Alex Universidad de Zaragoza (orcid)0000-0002-9723-9004 Guallar, David Universidad de Zaragoza Ruiz de Arcaute, Marta Universidad de Zaragoza (orcid)0000-0002-7655-2472 1009 773 Universidad de Zaragoza Dpto. Patología Animal Área Sanidad Animal 1009 617 Universidad de Zaragoza Dpto. Patología Animal Área Medicina y Cirugía Animal 16, 1 (2026), 17 [12 pp.] Animals (Basel) Animals 2076-2615 555246 http://zaguan.unizar.es/record/165363/files/texto_completo.pdf Versión publicada 2525499 http://zaguan.unizar.es/record/165363/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:165363 articulos driver 2026-03-18-13:57:56 ARTICLE