000165366 001__ 165366
000165366 005__ 20260107201858.0
000165366 0247_ $$2doi$$a10.1093/europace/euab080
000165366 0248_ $$2sideral$$a146824
000165366 037__ $$aART-2021-146824
000165366 041__ $$aeng
000165366 100__ $$0(orcid)0000-0001-9187-1773$$aJáuregui B
000165366 245__ $$aMANual vs. automatIC local activation time annotation for guiding Premature Ventricular Complex ablation procedures (MANIaC-PVC study).
000165366 260__ $$c2021
000165366 5060_ $$aAccess copy available to the general public$$fUnrestricted
000165366 5203_ $$aAims
To assess potential benefits of a local activation time (LAT) automatic acquisition protocol using wavefront annotation plus an ECG pattern matching algorithm [automatic (AUT)-arm] during premature ventricular complex (PVC) ablation procedures.
Methods and results
Prospective, randomized, controlled, and international multicentre study (NCT03340922). One hundred consecutive patients with indication for PVC ablation were enrolled and randomized to AUT (n = 50) or manual (MAN, n = 50) annotation protocols using the CARTO3 navigation system. The primary endpoint was mapping success. Clinical success was defined as a PVC-burden reduction of ≥80% in the 24-h Holter within 6 months after the procedure. Mean age was 56 ± 14 years, 54% men. The mean baseline PVC burden was 25 ± 13%, and mean left ventricular ejection fraction (LVEF) 55 ± 11%. Baseline characteristics were similar between the groups. The most frequent PVC-site of origin were right ventricular outflow tract (41%), LV (25%), and left ventricular outflow tract (17%), without differences between groups. Radiofrequency (RF) time and number of RF applications were similar for both groups. Mapping and procedure times were significantly shorter in the AUT-arm (25.5 ± 14.3 vs. 32.8 ± 12.6 min, P = 0.009; and 54.8 ± 24.8 vs. 67.4 ± 25.2, P = 0.014, respectively), while more mapping points were acquired [136 (94–222) AUT vs. 79 (52–111) MAN; P < 0.001]. Mapping and clinical success were similar in both groups. There were no procedure-related complications.
Conclusion
The use of a complete automatic protocol for LAT annotation during PVC ablation procedures allows to achieve similar clinical endpoints with higher procedural efficiency when compared with conventional, manual annotation carried out by expert operators.
000165366 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000165366 590__ $$a5.486$$b2021
000165366 591__ $$aCARDIAC & CARDIOVASCULAR SYSTEMS$$b46 / 143 = 0.322$$c2021$$dQ2$$eT1
000165366 592__ $$a1.957$$b2021
000165366 593__ $$aPhysiology (medical)$$c2021$$dQ1
000165366 593__ $$aCardiology and Cardiovascular Medicine$$c2021$$dQ1
000165366 594__ $$a9.5$$b2021
000165366 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000165366 700__ $$aFernández-Armenta J
000165366 700__ $$aAcosta J
000165366 700__ $$aPenela D
000165366 700__ $$aTerés C
000165366 700__ $$aOrdóñez A
000165366 700__ $$aSoto-Iglesias D
000165366 700__ $$aSilva E
000165366 700__ $$aChauca A
000165366 700__ $$aCarreño JM
000165366 700__ $$aScherer C
000165366 700__ $$aPedrote A
000165366 700__ $$aBerruezo A
000165366 773__ $$g23, 8 (2021), 1285–1294$$pEuropace$$tEuropace$$x1099-5129
000165366 8564_ $$s1086285$$uhttps://zaguan.unizar.es/record/165366/files/texto_completo.pdf$$yVersión publicada
000165366 8564_ $$s2163787$$uhttps://zaguan.unizar.es/record/165366/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000165366 909CO $$ooai:zaguan.unizar.es:165366$$particulos$$pdriver
000165366 951__ $$a2026-01-07-18:53:14
000165366 980__ $$aARTICLE