Long-term results of a phase 2 study of rituximab and bendamustine for mucosa-associated lymphoid tissue lymphoma

Salar, Antonio ; Domingo-Domenech, Eva ; Panizo, Carlos ; Nicolás, Concepción ; Bargay, Joan ; Muntañola, Ana ; Canales, Miguel ; Bello, José Luis ; Sancho, Juan Manuel ; Tomás, José Francisco ; Rodríguez, María José ; Peñalver, Javier ; Grande, Carlos ; Sánchez-Blanco, José Javier ; Palomera, Luis (Universidad de Zaragoza) ; Arranz, Reyes ; Conde, Eulogio ; García, Mar ; García, Juan Fernando ; Caballero, Dolores ; Montalbán, Carlos

Resumen: To the editor: Extranodal marginal zone B-cell lymphomas of mucosa-associated lymphoid tissue (MALT) present in most cases as localized disease and can be successfully treated with local therapies or antibiotics.1¿¿-4 Moreover, patients with multicentric or extensive disease or relapsed disease may require systemic treatment with chemotherapy and/or rituximab.5¿¿-8 Also, considering the relative frequency of late relapses9 and that extragastric MALT lymphomas have an increased relapse risk, 10 systemic treatment has also been used in the first-line setting. Several chemotherapy agents, anti-CD20 monoclonal antibodies, immunomodulatory agents, and their combinations have been demonstrated to be effective specifically in MALT lymphomas.11¿¿-14 Herewith, we report the long-term results of the MALT 2008-01 phase 2 trial15 using a response-adapted protocol with the combination of rituximab and bendamustine (RB) as first-line treatment of MALT lymphomas after a median follow-up of 7 years. This trial was registered at www.clinicaltrials.gov as #NCT01015248 and in EudraCT as #2008-007725-39....

Idioma: Inglés

DOI: 10.1182/blood-2017-07-795302

Año: 2017

Publicado en: Blood 130, 15 (2017), 1772-1774
ISSN: 0006-4971

Factor impacto JCR: 15.132 (2017)

Categ. JCR: HEMATOLOGY rank: 2 / 71 = 0.028 (2017) - Q1 - T1

Factor impacto SCIMAGO: 6.434 - Biochemistry (Q1) - Immunology (Q1) - Hematology (Q1) - Cell Biology (Q1)

Tipo y forma: (Versión definitiva)

Área (Departamento): Area Medicina (Dpto. Medicina, Psiqu. y Derm.)