000165413 001__ 165413
000165413 005__ 20260108143204.0
000165413 0247_ $$2doi$$a10.1016/j.jinf.2015.11.007
000165413 0248_ $$2sideral$$a143638
000165413 037__ $$aART-2016-143638
000165413 041__ $$aeng
000165413 100__ $$aRodríguez, Alejandro H.
000165413 245__ $$aProcalcitonin (PCT) levels for ruling-out bacterial coinfection in ICU patients with influenza: A CHAID decision-tree analysis
000165413 260__ $$c2016
000165413 5203_ $$aObjectives
To define which variables upon ICU admission could be related to the presence of coinfection using CHAID (Chi-squared Automatic Interaction Detection) analysis.
Methods
A secondary analysis from a prospective, multicentre, observational study (2009–2014) in ICU patients with confirmed A(H1N1)pdm09 infection. We assessed the potential of biomarkers and clinical variables upon admission to the ICU for coinfection diagnosis using CHAID analysis. Performance of cut-off points obtained was determined on the basis of the binominal distributions of the true (+) and true (−) results.
Results
Of the 972 patients included, 196 (20.3%) had coinfection. Procalcitonin (PCT; ng/mL 2.4 vs. 0.5, p < 0.001), but not C-reactive protein (CRP; mg/dL 25 vs. 38.5; p = 0.62) was higher in patients with coinfection. In CHAID analyses, PCT was the most important variable for coinfection. PCT <0.29 ng/mL showed high sensitivity (Se = 88.2%), low Sp (33.2%) and high negative predictive value (NPV = 91.9%). The absence of shock improved classification capacity. Thus, for PCT <0.29 ng/mL, the Se was 84%, the Sp 43% and an NPV of 94% with a post-test probability of coinfection of only 6%.
Conclusion
PCT has a high negative predictive value (94%) and lower PCT levels seems to be a good tool for excluding coinfection, particularly for patients without shock.
000165413 540__ $$9info:eu-repo/semantics/closedAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000165413 590__ $$a4.201$$b2016
000165413 591__ $$aINFECTIOUS DISEASES$$b16 / 84 = 0.19$$c2016$$dQ1$$eT1
000165413 592__ $$a2.049$$b2016
000165413 593__ $$aMicrobiology (medical)$$c2016$$dQ1
000165413 593__ $$aInfectious Diseases$$c2016$$dQ1
000165413 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000165413 700__ $$aAvilés-Jurado, Francesc X.
000165413 700__ $$aDíaz, Emili
000165413 700__ $$aSchuetz, Philipp
000165413 700__ $$aTrefler, Sandra I.
000165413 700__ $$aSolé-Violán, Jordi
000165413 700__ $$aCordero, Lourdes
000165413 700__ $$aVidaur, Loreto
000165413 700__ $$aEstella, Ángel
000165413 700__ $$aPozo Laderas, Juan C.
000165413 700__ $$aSocias, Lorenzo
000165413 700__ $$aVergara, Juan C.
000165413 700__ $$aZaragoza, Rafael
000165413 700__ $$aBonastre, Juan
000165413 700__ $$aGuerrero, José E.
000165413 700__ $$aSuberviola, Borja
000165413 700__ $$aCilloniz, Catia.
000165413 700__ $$aRestrepo, Marcos I.
000165413 700__ $$aMartín-Loeches, Ignacio
000165413 700__ $$aCobo, Pedro
000165413 700__ $$aMartins, Javier
000165413 700__ $$aCarbayo, Cecilia
000165413 700__ $$aRobles-Musso, Emilio
000165413 700__ $$aCárdenas, Antonio
000165413 700__ $$aFierro, Javier
000165413 700__ $$aFernández, Dolores Ocaña
000165413 700__ $$aSierra, Rafael
000165413 700__ $$aHuertos, Mª Jesús
000165413 700__ $$aCarmona Pérez, Mª Luz
000165413 700__ $$aPozo Laderas, Juan Carlos
000165413 700__ $$aGuerrero, R.
000165413 700__ $$aRobles, Juan Carlos
000165413 700__ $$aLeón, Melissa Echevarría
000165413 700__ $$aGómez, Alberto Bermejo
000165413 700__ $$aMárquez, Enrique
000165413 700__ $$aRodríguez-Carvajal, Manuel
000165413 700__ $$aEstella, Ángel
000165413 700__ $$aPomares, José
000165413 700__ $$aBallesteros, José Luis
000165413 700__ $$aRomero, Olga Moreno
000165413 700__ $$aFernández, Yolanda
000165413 700__ $$aLobato, Francisco
000165413 700__ $$aPrieto, José F.
000165413 700__ $$aAlbofedo-Sánchez, José
000165413 700__ $$aMartínez, Pilar
000165413 700__ $$ade la Torre, María Victoria
000165413 700__ $$aNieto, María
000165413 700__ $$aSola, Estefanía Camara
000165413 700__ $$aDíaz Castellanos, Miguel Angel
000165413 700__ $$aSoler, Guillermo Sevilla
000165413 700__ $$aLeyba, Carlos Ortiz
000165413 700__ $$aGarnacho-Montero, José
000165413 700__ $$aHinojosa, Rafael
000165413 700__ $$aFernández, Esteban
000165413 700__ $$aLoza, Ana
000165413 700__ $$aLeón, Cristóbal
000165413 700__ $$aLópez, Samuel González
000165413 700__ $$aArenzana, Angel
000165413 700__ $$aOcaña, Dolores
000165413 700__ $$aNavarrete, Inés
000165413 700__ $$aBeryanaki, Medhi Zaheri
000165413 700__ $$aSánchez, Ignacio
000165413 700__ $$aPérez Alé, Manuel
000165413 700__ $$aPoullet Brea, Ana Mª
000165413 700__ $$aMachado Casas, Juan Francisco
000165413 700__ $$0(orcid)0000-0002-8068-5016$$aSerón, Carlos$$uUniversidad de Zaragoza
000165413 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000165413 773__ $$g72, 2 (2016), 143-151$$pJ. infect.$$tJOURNAL OF INFECTION$$x0163-4453
000165413 8564_ $$s550285$$uhttps://zaguan.unizar.es/record/165413/files/texto_completo.pdf$$yVersión publicada
000165413 8564_ $$s2260291$$uhttps://zaguan.unizar.es/record/165413/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000165413 909CO $$ooai:zaguan.unizar.es:165413$$particulos$$pdriver
000165413 951__ $$a2026-01-08-14:10:11
000165413 980__ $$aARTICLE