165413 20260108143204.0 doi 10.1016/j.jinf.2015.11.007 sideral 143638 ART-2016-143638 eng Rodríguez, Alejandro H. Procalcitonin (PCT) levels for ruling-out bacterial coinfection in ICU patients with influenza: A CHAID decision-tree analysis 2016 Objectives To define which variables upon ICU admission could be related to the presence of coinfection using CHAID (Chi-squared Automatic Interaction Detection) analysis. Methods A secondary analysis from a prospective, multicentre, observational study (2009–2014) in ICU patients with confirmed A(H1N1)pdm09 infection. We assessed the potential of biomarkers and clinical variables upon admission to the ICU for coinfection diagnosis using CHAID analysis. Performance of cut-off points obtained was determined on the basis of the binominal distributions of the true (+) and true (−) results. Results Of the 972 patients included, 196 (20.3%) had coinfection. Procalcitonin (PCT; ng/mL 2.4 vs. 0.5, p < 0.001), but not C-reactive protein (CRP; mg/dL 25 vs. 38.5; p = 0.62) was higher in patients with coinfection. In CHAID analyses, PCT was the most important variable for coinfection. PCT <0.29 ng/mL showed high sensitivity (Se = 88.2%), low Sp (33.2%) and high negative predictive value (NPV = 91.9%). The absence of shock improved classification capacity. Thus, for PCT <0.29 ng/mL, the Se was 84%, the Sp 43% and an NPV of 94% with a post-test probability of coinfection of only 6%. Conclusion PCT has a high negative predictive value (94%) and lower PCT levels seems to be a good tool for excluding coinfection, particularly for patients without shock. info:eu-repo/semantics/closedAccess All rights reserved http://www.europeana.eu/rights/rr-f/ 4.201 2016 INFECTIOUS DISEASES 16 / 84 = 0.19 2016 Q1 T1 2.049 2016 Microbiology (medical) 2016 Q1 Infectious Diseases 2016 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Avilés-Jurado, Francesc X. Díaz, Emili Schuetz, Philipp Trefler, Sandra I. Solé-Violán, Jordi Cordero, Lourdes Vidaur, Loreto Estella, Ángel Pozo Laderas, Juan C. Socias, Lorenzo Vergara, Juan C. Zaragoza, Rafael Bonastre, Juan Guerrero, José E. Suberviola, Borja Cilloniz, Catia. Restrepo, Marcos I. Martín-Loeches, Ignacio Cobo, Pedro Martins, Javier Carbayo, Cecilia Robles-Musso, Emilio Cárdenas, Antonio Fierro, Javier Fernández, Dolores Ocaña Sierra, Rafael Huertos, Mª Jesús Carmona Pérez, Mª Luz Pozo Laderas, Juan Carlos Guerrero, R. Robles, Juan Carlos León, Melissa Echevarría Gómez, Alberto Bermejo Márquez, Enrique Rodríguez-Carvajal, Manuel Estella, Ángel Pomares, José Ballesteros, José Luis Romero, Olga Moreno Fernández, Yolanda Lobato, Francisco Prieto, José F. Albofedo-Sánchez, José Martínez, Pilar de la Torre, María Victoria Nieto, María Sola, Estefanía Camara Díaz Castellanos, Miguel Angel Soler, Guillermo Sevilla Leyba, Carlos Ortiz Garnacho-Montero, José Hinojosa, Rafael Fernández, Esteban Loza, Ana León, Cristóbal López, Samuel González Arenzana, Angel Ocaña, Dolores Navarrete, Inés Beryanaki, Medhi Zaheri Sánchez, Ignacio Pérez Alé, Manuel Poullet Brea, Ana Mª Machado Casas, Juan Francisco Serón, Carlos Universidad de Zaragoza (orcid)0000-0002-8068-5016 1007 610 Universidad de Zaragoza Dpto. Medicina, Psiqu. y Derm. Area Medicina 72, 2 (2016), 143-151 J. infect. JOURNAL OF INFECTION 0163-4453 550285 http://zaguan.unizar.es/record/165413/files/texto_completo.pdf Versión publicada 2260291 http://zaguan.unizar.es/record/165413/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:165413 articulos driver 2026-01-08-14:10:11 ARTICLE