000165420 001__ 165420
000165420 005__ 20260108143204.0
000165420 0247_ $$2doi$$a10.1002/ajhb.70176
000165420 0248_ $$2sideral$$a147237
000165420 037__ $$aART-2025-147237
000165420 041__ $$aeng
000165420 100__ $$aAixa-Requena, Saül
000165420 245__ $$aHigh‐Sensitivity Cardiac Troponin T in Healthy Sport‐Participating Youth Aged 8–16 Years: Reference Values From the Cor‐School Cohort
000165420 260__ $$c2025
000165420 5060_ $$aAccess copy available to the general public$$fUnrestricted
000165420 5203_ $$aObjectivesHigh-sensitivity cardiac troponin T (hs-cTnT) is widely used in adult cardiology, yet pediatric reference values remain scarce. This study aimed to establish reference values for hs-cTnT in healthy sport-participating youth aged 8–16 years from Spain; to examine differences by age, sex, and pubertal stage; and to explore associations with anthropometry and physical activity.MethodsThis cross-sectional study used baseline data from the Cor-School cohort, including 733 organized sport participants aged 8–16 years from northeastern Spain. Anthropometry, pubertal status, biological maturity, and PHV timing were assessed alongside hs-cTnT and habitual physical activity. Percentiles were calculated from detectable hs-cTnT concentrations below the 99.75th percentile. Group comparisons, correlations, and regression models examined developmental patterns.ResultsAmong 733 youth, 39% had detectable hs-cTnT and 4.7% exceeded 14 ng/L. The 97.5th and 99th percentiles were 15.2 ng/L (90% CI: 12.4–16.9) and 19.1 ng/L (90% CI: 15.2–21.3), peaking in early adolescence (11–13 years) and around PHV. Tanner Stage 4 showed the highest 99th percentile (20.4 ng/L), while Tanner 5 had lower values. Boys presented greater detectability (42% vs. 33%) and higher percentiles (99th: 19.1 vs. 15.6 ng/L). hs-cTnT correlated weakly with maturity offset (ρ = 0.183, p = 0.002) and inversely with body fat (ρ = −0.170, p = 0.040), but no independent predictors remained in multivariable models (R2 adj = 0.033).Conclusionshs-cTnT increases physiologically during adolescence, reflecting biological maturation. Pediatric-specific reference values by age and developmental stage are recommended to avoid misclassification. As all participants were regularly engaged in organized sport, the reference values obtained likely represent the upper end of physiological hs-cTnT concentrations in physically active youth.
000165420 536__ $$9info:eu-repo/grantAgreement/ES/AEI/PID2020-117932RB-I00
000165420 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es
000165420 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000165420 700__ $$aConesa-Milian, Enric
000165420 700__ $$aHernández-González, Vicenç
000165420 700__ $$0(orcid)0000-0002-7213-7095$$aPuente-Lanzarote, Juan José
000165420 700__ $$0(orcid)0000-0002-9304-3709$$aLópez-Laval, Isaac$$uUniversidad de Zaragoza
000165420 700__ $$ade Pano-Rodríguez, Álvaro
000165420 700__ $$aReverter-Masià, Joaquín
000165420 7102_ $$11006$$2245$$aUniversidad de Zaragoza$$bDpto. Fisiatría y Enfermería$$cÁrea Educación Física y Depor.
000165420 773__ $$g37, 12 (2025), e70176 [12 pp.]$$pAm. j. human biol.$$tAMERICAN JOURNAL OF HUMAN BIOLOGY$$x1042-0533
000165420 8564_ $$s480166$$uhttps://zaguan.unizar.es/record/165420/files/texto_completo.pdf$$yVersión publicada
000165420 8564_ $$s2353166$$uhttps://zaguan.unizar.es/record/165420/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000165420 909CO $$ooai:zaguan.unizar.es:165420$$particulos$$pdriver
000165420 951__ $$a2026-01-08-14:10:19
000165420 980__ $$aARTICLE