000165434 001__ 165434
000165434 005__ 20260108143204.0
000165434 0247_ $$2doi$$a10.1111/jgs.12152
000165434 0248_ $$2sideral$$a118441
000165434 037__ $$aART-2013-118441
000165434 041__ $$aeng
000165434 100__ $$aGarnacho-Montero, José
000165434 245__ $$aEpidemiology, Clinical Features, and Prognosis of Elderly Adultswith Severe Forms of Influenza A (H1N1)
000165434 260__ $$c2013
000165434 5203_ $$aObjectives: To examine epidemiological and clinical data of individuals aged 65 and older with influenza virus A (H 1N 1) admitted to the intensive care unit (ICU ) and to identify independent predictors of ICU mortality.
Design: Prospective, observational, multicenter study to determine prognostic factors in individuals infected with influenza A (H 1N 1) admitted to the ICU.
Setting: One hundred forty‐eight S panish ICU s.
Participants: Individuals with influenza A (H 1N 1) confirmed using real‐time polymerase chain reaction from A pril 2009 to J uly 2011.
Measurements: Individuals aged 65 and older were compared with younger individuals. A multivariate analysis was conducted to determine independent predictors of mortality in this population.
Results: One thousand one hundred twenty individuals (129 (11.5%) aged ≥65) were included. Prevalence of chronic diseases was more common in older individuals. Viral pneumonitis was more frequent in individuals younger than 65 (70.5% vs 54.3%, P < .001). In older individuals, A cute P hysiology and C hronic H ealth E valuation II score (odds ratio (OR ) = 1.11, 95% confidence interval (CI ) = 1.11–1.20, P = .002), immunosuppression (OR = 3.66, 95% CI , 1.33–10.03, P = .01) and oseltamivir therapy initiated after 48 hours (OR = 3.32, 95% CI = 1.02–10.8, P = .04) were identified as independent variables associated with mortality. Corticosteroid use was associated with a trend toward greater mortality (OR = 2.39, 95% CI = 0.98–5.91, P = .06).
Conclusion: Individuals aged 65 and older with influenza A (H 1N 1) admitted to the ICU have a higher incidence of underlying diseases than younger individuals and differences in clinical presentation. Early oseltamivir therapy is associated with better outcomes in elderly adults.
000165434 540__ $$9info:eu-repo/semantics/closedAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000165434 590__ $$a4.216$$b2013
000165434 591__ $$aGERONTOLOGY$$b2 / 31 = 0.065$$c2013$$dQ1$$eT1
000165434 591__ $$aGERIATRICS & GERONTOLOGY$$b6 / 49 = 0.122$$c2013$$dQ1$$eT1
000165434 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000165434 700__ $$aGutiérrez-Pizarraya, Antonio
000165434 700__ $$aMarquez, Juan A.
000165434 700__ $$aZaragoza, Rafael
000165434 700__ $$aGranada, Rosa
000165434 700__ $$aRuiz-Santana, Sergio
000165434 700__ $$aRello, Jordi
000165434 700__ $$aRodríguez, Alejandro
000165434 700__ $$0(orcid)0000-0002-8068-5016$$aSerón Arbeloa, Carlos
000165434 700__ $$abehalf of the Spanish Society of Intensive Care Medicineand Coronary Units Working Group
000165434 773__ $$g61, 3 (2013), 350-366$$pJ. Am. Geriatr. Soc.$$tJournal of the American Geriatrics Society$$x0002-8614
000165434 8564_ $$s97446$$uhttps://zaguan.unizar.es/record/165434/files/texto_completo.pdf$$yVersión publicada
000165434 8564_ $$s2746229$$uhttps://zaguan.unizar.es/record/165434/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000165434 909CO $$ooai:zaguan.unizar.es:165434$$particulos$$pdriver
000165434 951__ $$a2026-01-08-14:10:34
000165434 980__ $$aARTICLE