165457 20260108143204.0 doi 10.23938/ASSN.1136 sideral 147028 ART-2025-147028 eng Gómez-Soria, I. Universidad de Zaragoza (orcid)0000-0002-0061-3312 Differential effects of computerized cognitive stimulation versus stimulating leisure activities on mood and global cognition in adults with subjective and mild cognitive impairment: A randomized controlled trial 2025 Background. Mild Cognitive Impairment (MCI) involves both subjective and objective cognitive decline with relatively preserved daily functioning, whereas Subjective Cognitive Impairment (SCI) refers to perceived decline without measurable deficits. This study aimed to compare the effects of a personalized computerized cognitive stimulation (CS) program (IG1) and a stimulating leisure activities program (IG2) in adults with MCI and SCI. Methods. A single-blind randomized controlled trial was conducted in primary care with participants aged ≥50 years with SCI or MCI. Participants were randomized to IG1, IG2), or a control group (CG). IG1 completed personalized computerized CS for 30 minutes/day, 5 days/week, for 8 weeks. IG2 engaged in 2-5 stimulating leisure activities per week for the same period. The primary outcome was global cognition; secondary outcomes included memory, verbal fluency, daily functioning, and mood. Results. Fifty-nine participants were enrolled in the study, 44 with SCI and 15 with MCI. Compared to CG, IG1 showed greater reductions in anxiety post-intervention (2.07; 95%CI: 0.93-3.22 vs. 4.34; 95%CI: 3.22-5.46) and lower depressive symptoms at 6-month follow-up (3.41; 95%CI: 2.05-4.77 vs. 5.62; 95%CI: 4.26-6.97). IG2 participants demonstrated improved global cognition post-intervention (29.2; 95%CI: 27.625-30.776) and at 6 months (28.78; 95%CI: 27.16- 30.42) relative to CG (30.626; 95%CI: 28.99-32.27). Conclusion. Personalized computerized CS reduces anxiety and depression symptoms, while stimulating leisure activities enhances global cognition in community-dwelling adults with SCI and MCI, suggesting complementary benefits of both interventions. Keywords. Mild Cognitive Impairment. Subjective Cognitive Impairment. Computerized Cognitive Stimulation. Stimulating Leisure Activities. Primary Care Access copy available to the general public Unrestricted info:eu-repo/grantAgreement/ES/DGA/B21-23R-GAIAP info:eu-repo/semantics/openAccess by-sa https://creativecommons.org/licenses/by-sa/4.0/deed.es info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Cuenca-Zaldivar, J. N. Oliván-Blázquez, B. Universidad de Zaragoza (orcid)0000-0001-6565-9699 Aguilar Latorre, A. Universidad de Zaragoza (orcid)0000-0003-2683-7346 Magallón-Botaya, R. M., Universidad de Zaragoza (orcid)0000-0002-5494-6550 Calatayud, E. Universidad de Zaragoza (orcid)0000-0002-4307-796X 4009 740 Universidad de Zaragoza Dpto. Psicología y Sociología Área Psicología Social 1007 610 Universidad de Zaragoza Dpto. Medicina, Psiqu. y Derm. Area Medicina 1006 413 Universidad de Zaragoza Dpto. Fisiatría y Enfermería Área Fisioterapia 4009 735 Universidad de Zaragoza Dpto. Psicología y Sociología Área Psicolog.Evolut.Educac 48, 3 (2025), e1136 An. sist. sanit. Navar. Anales del Sistema Sanitario de Navarra 1137-6627 686525 http://zaguan.unizar.es/record/165457/files/texto_completo.pdf Versión publicada 3320947 http://zaguan.unizar.es/record/165457/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:165457 articulos driver 2026-01-08-14:10:58 ARTICLE