000165519 001__ 165519
000165519 005__ 20260112132214.0
000165519 0247_ $$2doi$$a10.3390/cells11121864
000165519 0248_ $$2sideral$$a147101
000165519 037__ $$aART-2022-147101
000165519 041__ $$aeng
000165519 100__ $$aYang, Chen Xi
000165519 245__ $$aLung Spatial Profiling Reveals a T Cell Signature in COPD Patients with Fatal SARS-CoV-2 Infection
000165519 260__ $$c2022
000165519 5203_ $$aPeople with pre-existing lung diseases such as chronic obstructive pulmonary disease (COPD) are more likely to get very sick from SARS-CoV-2 disease 2019 (COVID-19). Still, an interrogation of the immune response to COVID-19 infection, spatially throughout the lung structure, is lacking in patients with COPD. For this study, we characterized the immune microenvironment of the lung parenchyma, airways, and vessels of never- and ever-smokers with or without COPD, all of whom died of COVID-19, using spatial transcriptomic and proteomic profiling. The parenchyma, airways, and vessels of COPD patients, compared to control lungs had (1) significant enrichment for lung-resident CD45RO+ memory CD4+ T cells; (2) downregulation of genes associated with T cell antigen priming and memory T cell differentiation; and (3) higher expression of proteins associated with SARS-CoV-2 entry and primary receptor ubiquitously across the ROIs and in particular the lung parenchyma, despite similar SARS-CoV-2 structural gene expression levels. In conclusion, the lung parenchyma, airways, and vessels of COPD patients have increased T-lymphocytes with a blunted memory CD4 T cell response and a more invasive SARS-CoV-2 infection pattern and may underlie the higher death toll observed with COVID-19.
000165519 540__ $$9info:eu-repo/semantics/closedAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es
000165519 590__ $$a6.0$$b2022
000165519 591__ $$aCELL BIOLOGY$$b60 / 191 = 0.314$$c2022$$dQ2$$eT1
000165519 592__ $$a1.537$$b2022
000165519 593__ $$aBiochemistry, Genetics and Molecular Biology (miscellaneous)$$c2022$$dQ1
000165519 594__ $$a9.0$$b2022
000165519 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000165519 700__ $$aTomchaney, Michael
000165519 700__ $$aLandecho, Manuel F.
000165519 700__ $$aZamacona, Borja R.
000165519 700__ $$0(orcid)0000-0003-0777-3850$$aMarin Oto, Marta$$uUniversidad de Zaragoza
000165519 700__ $$aZulueta, Javier
000165519 700__ $$aMalo, Joshua
000165519 700__ $$aKnoper, Steve
000165519 700__ $$aContoli, Marco
000165519 700__ $$aPapi, Alberto
000165519 700__ $$aVasilescu, Dragos M.
000165519 700__ $$aSauler, Maor
000165519 700__ $$aStraub, Christof
000165519 700__ $$aTan, Cheryl
000165519 700__ $$aMartinez, Fernando D.
000165519 700__ $$aBhattacharya, Deepta
000165519 700__ $$aRosas, Ivan O.
000165519 700__ $$aKheradmand, Farrah
000165519 700__ $$aHackett, Tillie-Louise
000165519 700__ $$aPolverino, Francesca
000165519 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000165519 773__ $$g11, 12 (2022), 1864 [15 pp.]$$pCells$$tCells$$x2073-4409
000165519 8564_ $$s1934049$$uhttps://zaguan.unizar.es/record/165519/files/texto_completo.pdf$$yVersión publicada
000165519 8564_ $$s2383927$$uhttps://zaguan.unizar.es/record/165519/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000165519 909CO $$ooai:zaguan.unizar.es:165519$$particulos$$pdriver
000165519 951__ $$a2026-01-12-11:09:07
000165519 980__ $$aARTICLE