000165526 001__ 165526
000165526 005__ 20260112132215.0
000165526 0247_ $$2doi$$a10.1523/JNEUROSCI.2343-24.2025
000165526 0248_ $$2sideral$$a144788
000165526 037__ $$aART-2025-144788
000165526 041__ $$aeng
000165526 100__ $$aHe, Ying
000165526 245__ $$aRegional Excitatory–Inhibitory Balance Relates to Self-Reference Effect on Recollection via the Precuneus/Posterior Cingulate Cortex–Medial Prefrontal Cortex Connectivity
000165526 260__ $$c2025
000165526 5060_ $$aAccess copy available to the general public$$fUnrestricted
000165526 5203_ $$aSelf-related representation can enhance perception and memory—a phenomenon known as the self-referential effect (SRE). While SRE has been linked to the activation of the default mode network (DMN), including the precuneus/posterior cingulate cortex (Pcu/PCC) and the medial prefrontal cortex (mPFC), the underlying neurochemical processes of DMN activations remain unclear. The balance of excitation and inhibition (E/I balance) within brain circuits is crucial for cognition and may play a role in the SRE. We examine whether the ratio of glutamate/glutamine (Glx) to γ-aminobutyric acid (GABA) concentrations, measured by 1H-magnetic resonance spectroscopy (1H-MRS) as a proxy measure for E/I balance, is associated with DMN neural processes involved in self-referential encoding. Fifty-four healthy participants aged 7–35 (25 female) underwent MRS to measure levels of Glx and GABA in Pcu/PCC and completed an fMRI scan during an encoding task that involved self-referential and semantic judgments. We found that the self-related condition led to better subsequent memory and greater activation in the Pcu/PCC compared with the semantic condition. Activations in the Pcu/PCC were positively correlated with the Glx/GABA+ ratio. Task-dependent functional connectivity analysis revealed that connectivity between the Pcu/PCC and medial prefrontal cortex (mPFC) was positively associated with both the Glx/GABA+ ratio and the SRE effect on recollection accuracy. Furthermore, mediation analysis showed that a higher Glx/GABA+ ratio correlated with better SRE on memory recollection through increased Pcu/PCC–mPFC connectivity. Our study provides valuable insights into how neurochemical activity is associated with self-related cognition via functional connectivity of large-scale brain networks
000165526 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000165526 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000165526 700__ $$aSweatman, Hilary
000165526 700__ $$aThomson, Alice R.
000165526 700__ $$0(orcid)0000-0003-2461-8588$$aGracia-Tabuenca, Zeus$$uUniversidad de Zaragoza
000165526 700__ $$aPuts, Nicolaas A.
000165526 700__ $$aChai, Xiaoqian J.
000165526 7102_ $$12007$$2265$$aUniversidad de Zaragoza$$bDpto. Métodos Estadísticos$$cÁrea Estadís. Investig. Opera.
000165526 773__ $$g45, 25 (2025), e2343242025 [9 pp.]$$pJ. neurosci.$$tJOURNAL OF NEUROSCIENCE$$x0270-6474
000165526 8564_ $$s968847$$uhttps://zaguan.unizar.es/record/165526/files/texto_completo.pdf$$yVersión publicada
000165526 8564_ $$s2637276$$uhttps://zaguan.unizar.es/record/165526/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000165526 909CO $$ooai:zaguan.unizar.es:165526$$particulos$$pdriver
000165526 951__ $$a2026-01-12-11:09:18
000165526 980__ $$aARTICLE