000165532 001__ 165532
000165532 005__ 20260112132215.0
000165532 0247_ $$2doi$$a10.1111/1469-0691.12339
000165532 0248_ $$2sideral$$a144423
000165532 037__ $$aART-2014-144423
000165532 041__ $$aeng
000165532 100__ $$aHarrois, D.
000165532 245__ $$aPrevalence and characterization of extended-spectrum ß-lactamase-producing clinical Salmonella enterica isolates in Dakar, Senegal, from 1999 to 2009
000165532 260__ $$c2014
000165532 5060_ $$aAccess copy available to the general public$$fUnrestricted
000165532 5203_ $$aA total of 1623 clinical isolates of Salmonella belonging to 229 serotypes were received by the Senegalese Reference Center for Enterobacteria from January 1999 to December 2009. The most common serotypes were Enteritidis (19% of the isolates), Typhi (8%), Typhimurium (7%) and Kentucky (4%). A significant increase in the prevalence of resistance to amoxicillin (0.9% in 1999 to 11.1% in 2009) and nalidixic acid (0.9% in 1999 to 26.7% in 2009) was observed in non-typhoidal Salmonella serotypes. For critically important antibiotics, notably ciprofloxacin and extended-spectrum cephalosporins (ESCs), the rates of resistance were low: 0.3% and 0.5%, respectively. Seven ESC-resistant Salmonella strains and three additional ESC-resistant strains from Senegal (1990) and Mali (2007) were studied to identify the genetic basis of their antibiotic resistance. All ESC-resistant strains produced an extended-spectrum ß-lactamase (ESBL). These were CTX-M-15 (n = 6; 2000–2008), SHV-12 (n = 3; 2000–2001) and SHV-2 (n = 1; 1990). A large IncHI2 ST1 pK29-like plasmid was found in six strains (three producing SHV-12 and three CTX-M-15), whereas IncN and IncF plasmids were found in three strains and one strain, respectively. The association of plasmid-mediated quinolone resistance (PMQR) genes qnrB1 and aac(6')-Ib-cr was found in four ESBL-producing strains, leading to decreased susceptibility and even full resistance to ciprofloxacin (MIC range 0.75–2 mg/L) despite the absence of mutations in the quinolone resistance-determining region (QRDR) of gyrA, gyrB, parC and parE. This association of ESBL and multiple PMQR mechanisms within the same strains is therefore a serious concern as it hampers the use of both ESCs and fluoroquinolones for severe Salmonella infections.
000165532 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000165532 590__ $$a5.768$$b2014
000165532 591__ $$aMICROBIOLOGY$$b16 / 119 = 0.134$$c2014$$dQ1$$eT1
000165532 591__ $$aINFECTIOUS DISEASES$$b5 / 78 = 0.064$$c2014$$dQ1$$eT1
000165532 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000165532 700__ $$aBreurec, S.
000165532 700__ $$aSeck, A.
000165532 700__ $$aDelaune, A.
000165532 700__ $$aLe Hello, S.
000165532 700__ $$0(orcid)0000-0002-3273-6392$$aPardos de la Gandara, M.
000165532 700__ $$aSontag, L.
000165532 700__ $$aPerrier-Gros-Claude, J-D.
000165532 700__ $$aSire, J-M.
000165532 700__ $$aGarin, B.
000165532 700__ $$aWeill, F-X.
000165532 773__ $$g20, 2 (2014), O109-O116$$pClin. microbiol. infect.$$tClinical Microbiology and Infection$$x1198-743X
000165532 8564_ $$s272353$$uhttps://zaguan.unizar.es/record/165532/files/texto_completo.pdf$$yPostprint
000165532 8564_ $$s910525$$uhttps://zaguan.unizar.es/record/165532/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000165532 909CO $$ooai:zaguan.unizar.es:165532$$particulos$$pdriver
000165532 951__ $$a2026-01-12-11:09:27
000165532 980__ $$aARTICLE