000165620 001__ 165620 000165620 005__ 20260112132217.0 000165620 0247_ $$2doi$$a10.1039/d5ob01129a 000165620 0248_ $$2sideral$$a147248 000165620 037__ $$aART-2025-147248 000165620 041__ $$aeng 000165620 100__ $$0(orcid)0000-0001-6832-8983$$aMorales-Solís, Juan Carlos$$uUniversidad de Zaragoza 000165620 245__ $$aOrganocatalysed C-2 and C-3 functionalisation of chromones 000165620 260__ $$c2025 000165620 5060_ $$aAccess copy available to the general public$$fUnrestricted 000165620 5203_ $$aThis review highlights the recent advancements in organocatalysed Michael addition reactions involving chromones, an important class of heterocyclic compounds with significant biological and pharmacological properties. Chromones, with their versatile conjugated structure, act as both electrophilic and nucleophilic partners, providing an ideal platform to synthesise diverse stereochemically enriched molecular frameworks. The work highlights various organocatalysed examples using chiral carbenes, phosphoric acids, thioureas and squaramides, that have demonstrated high efficiency and stereocontrol in a range of reactions. Mechanistic insights into how these catalytic systems activate the chromone scaffold and promote enantioselective transformations are also discussed in detail. Finally, we underline emerging trends and future directions in this research area, addressing current limitations, such as the need for more efficient catalytic systems and broader substrate compatibility. 000165620 536__ $$9info:eu-repo/grantAgreement/ES/DGA/E07-23R$$9info:eu-repo/grantAgreement/ES/MICIU/AEI/10.13039/501100011033 000165620 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc$$uhttps://creativecommons.org/licenses/by-nc/4.0/deed.es 000165620 655_4 $$ainfo:eu-repo/semantics/review$$vinfo:eu-repo/semantics/acceptedVersion 000165620 700__ $$aOrdoñez, Mario 000165620 700__ $$aMarqués-López, Eugenia 000165620 700__ $$0(orcid)0000-0002-5244-9569$$aHerrera, Raquel P. 000165620 7102_ $$12013$$2765$$aUniversidad de Zaragoza$$bDpto. Química Orgánica$$cÁrea Química Orgánica 000165620 773__ $$g23, 46 (2025), 10420-10436$$pOrg. biomol. chem.$$tOrganic & Biomolecular Chemistry$$x1477-0520 000165620 8564_ $$s7170291$$uhttps://zaguan.unizar.es/record/165620/files/texto_completo.pdf$$yPostprint 000165620 8564_ $$s2717506$$uhttps://zaguan.unizar.es/record/165620/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint 000165620 909CO $$ooai:zaguan.unizar.es:165620$$particulos$$pdriver 000165620 951__ $$a2026-01-12-11:11:22 000165620 980__ $$aARTICLE