165620 20260112132217.0 doi 10.1039/d5ob01129a sideral 147248 ART-2025-147248 eng Morales-Solís, Juan Carlos Universidad de Zaragoza (orcid)0000-0001-6832-8983 Organocatalysed C-2 and C-3 functionalisation of chromones 2025 This review highlights the recent advancements in organocatalysed Michael addition reactions involving chromones, an important class of heterocyclic compounds with significant biological and pharmacological properties. Chromones, with their versatile conjugated structure, act as both electrophilic and nucleophilic partners, providing an ideal platform to synthesise diverse stereochemically enriched molecular frameworks. The work highlights various organocatalysed examples using chiral carbenes, phosphoric acids, thioureas and squaramides, that have demonstrated high efficiency and stereocontrol in a range of reactions. Mechanistic insights into how these catalytic systems activate the chromone scaffold and promote enantioselective transformations are also discussed in detail. Finally, we underline emerging trends and future directions in this research area, addressing current limitations, such as the need for more efficient catalytic systems and broader substrate compatibility. Access copy available to the general public Unrestricted info:eu-repo/grantAgreement/ES/DGA/E07-23R info:eu-repo/grantAgreement/ES/MICIU/AEI/10.13039/501100011033 info:eu-repo/semantics/openAccess by-nc https://creativecommons.org/licenses/by-nc/4.0/deed.es info:eu-repo/semantics/review info:eu-repo/semantics/acceptedVersion Ordoñez, Mario Marqués-López, Eugenia Herrera, Raquel P. (orcid)0000-0002-5244-9569 2013 765 Universidad de Zaragoza Dpto. Química Orgánica Área Química Orgánica 23, 46 (2025), 10420-10436 Org. biomol. chem. Organic & Biomolecular Chemistry 1477-0520 7170291 http://zaguan.unizar.es/record/165620/files/texto_completo.pdf Postprint 2717506 http://zaguan.unizar.es/record/165620/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:165620 articulos driver 2026-01-12-11:11:22 ARTICLE