000165885 001__ 165885
000165885 005__ 20260115140311.0
000165885 0247_ $$2doi$$a10.22465/juo.255000080004
000165885 0248_ $$2sideral$$a147428
000165885 037__ $$aART-2025-147428
000165885 041__ $$aeng
000165885 100__ $$aSanz del Pozo, Mónica$$uUniversidad de Zaragoza
000165885 245__ $$aExpression and Prognostic Value of VEGF, VEGFR1, VEGFR2, VEGFR3, and E-Cadherin in Clear Cell Renal Cell Carcinoma
000165885 260__ $$c2025
000165885 5060_ $$aAccess copy available to the general public$$fUnrestricted
000165885 5203_ $$aPurpose: Clear cell renal cell carcinoma (ccRCC) is the most common histological subtype of renal carcinoma, accounting for 75%–80% of cases. Vascular endothelial growth factor (VEGF), which promotes angiogenesis via its membrane receptors (VEGFRs), and E-cadherin, which decreases in expression during invasion and metastasis, are both implicated in ccRCC pathogenesis. We analyzed the relationship between these proteins and ccRCC lesions to assess their usefulness as prognostic markers.Materials and Methods: Renal tumor tissue samples from nephrectomies of 69 patients were analyzed using immunohistochemical techniques to evaluate the expression of the aforementioned proteins. These findings were then compared with established prognostic scales. Statistical analysis was performed using SPSS Statistics ver. 29.0.1.0.Results: VEGF intensity was significantly correlated with tumor size (T; p=0.002), stage (p<0.001), and metastasis (M; p=0.049) according to the TNM classification. VEGFR3 expression correlated positively with tumor size (T; p=0.046) and stage (p=0.040). E-cadherin expression correlated negatively with tumor size (p=0.047). In relation to prognostic scales, VEGF expression correlated with the UCLA Integrated Staging System score (p=0.009), while E-cadherin correlated with the stage, size, grade and necrosis (SSIGN) score (p=0.044). For both overall and disease-free survival, significant differences were observed between the moderate (2++) and intense (3+++) VEGFR3 intensity groups (p=0.009 for both).Conclusion: VEGF may have prognostic value due to its association with tumor size, stage, metastasis, and the UCLA Integrated Staging System score. Similarly, VEGFR3 shows prognostic potential based on its correlations with tumor size, stage, and its relation to overall and disease-free survival. E-cadherin also demonstrates prognostic significance through its association with tumor size and the SSIGN score.
000165885 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc$$uhttps://creativecommons.org/licenses/by-nc/4.0/deed.es
000165885 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000165885 700__ $$aGimeno Pelegrín, Joaquín$$uUniversidad de Zaragoza
000165885 700__ $$aRodriguez Muñoz, Nebay
000165885 700__ $$aUtrilla Berberana, Diana
000165885 700__ $$aBascuas Hernandez, Javier
000165885 700__ $$aLópez del Val, Alejandro
000165885 700__ $$aGómez Barrera, Manuel
000165885 700__ $$aAzúa Romeo, Javier
000165885 700__ $$aCapapé Poves, Victoria$$uUniversidad de Zaragoza
000165885 700__ $$0(orcid)0000-0003-0178-4567$$aBorque Fernando, Ángel$$uUniversidad de Zaragoza
000165885 700__ $$0(orcid)0000-0002-2328-9236$$aSánchez Zalabardo, José Manuel
000165885 700__ $$0(orcid)0000-0003-2627-5953$$aSáez Gutiérrez, Berta
000165885 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000165885 7102_ $$11013$$2817$$aUniversidad de Zaragoza$$bDpto. Cirugía$$cÁrea Urología
000165885 773__ $$g23, 2 (2025), 132-139$$pJUO$$tJournal of Urologic Oncology$$x2951-603X
000165885 8564_ $$s554502$$uhttps://zaguan.unizar.es/record/165885/files/texto_completo.pdf$$yVersión publicada
000165885 8564_ $$s2432570$$uhttps://zaguan.unizar.es/record/165885/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000165885 909CO $$ooai:zaguan.unizar.es:165885$$particulos$$pdriver
000165885 951__ $$a2026-01-15-12:37:17
000165885 980__ $$aARTICLE