000165902 001__ 165902
000165902 005__ 20260116002211.0
000165902 0247_ $$2doi$$a10.1111/cmi.12169
000165902 0248_ $$2sideral$$a84683
000165902 037__ $$aART-2013-84683
000165902 041__ $$aeng
000165902 100__ $$0(orcid)0000-0001-7897-9173$$aAguiló, JI$$uUniversidad de Zaragoza
000165902 245__ $$aESX-1-induced apoptosis is involved in cell-to-cell spread of Mycobacterium tuberculosis.
000165902 260__ $$c2013
000165902 5060_ $$aAccess copy available to the general public$$fUnrestricted
000165902 5203_ $$aApoptosis modulation is a procedure amply utilized by intracellular pathogens to favour the outcome of the infection. Nevertheless, the role of apoptosis during infection with Mycobacterium tuberculosis, the causative agent of human tuberculosis, is subject of an intense debate and still remains unclear. In this work, we describe that apoptosis induction in host cells is clearly restricted to virulent M. tuberculosis strains, and is associated with the capacity of the mycobacteria to secrete the 6 kDa early secreted antigenic target ESAT-6 both under in vitro and in vivo conditions. Remarkably, only apoptosis-inducing strains are able to propagate infection into new cells, suggesting that apoptosis is used by M. tuberculosis as a colonization mechanism. Finally, we demonstrate that in vitro modulation of apoptosis affects mycobacterial cell-to-cell spread capacity, establishing an unambiguous relationship between apoptosis and propagation of M. tuberculosis. Our data further indicate that BCG and MTBVAC vaccines are inefficient in inducing apoptosis and colonizing new cells, correlating with the strong attenuation profile of these strains previously observed in vitro and in vivo.
000165902 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000165902 590__ $$a4.816$$b2013
000165902 591__ $$aMICROBIOLOGY$$b20 / 118 = 0.169$$c2013$$dQ1$$eT1
000165902 591__ $$aCELL BIOLOGY$$b55 / 184 = 0.299$$c2013$$dQ2$$eT1
000165902 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000165902 700__ $$0(orcid)0000-0003-2742-8827$$aAlonso, H$$uUniversidad de Zaragoza
000165902 700__ $$0(orcid)0000-0001-7866-2803$$aUranga, S$$uUniversidad de Zaragoza
000165902 700__ $$0(orcid)0000-0001-8644-120X$$aMarinova, D$$uUniversidad de Zaragoza
000165902 700__ $$0(orcid)0000-0002-3377-4171$$aArbués, A
000165902 700__ $$ade Martino, A
000165902 700__ $$0(orcid)0000-0002-5175-8394$$aAnel, A$$uUniversidad de Zaragoza
000165902 700__ $$aMonzon, M
000165902 700__ $$0(orcid)0000-0002-7173-7216$$aBadiola, J$$uUniversidad de Zaragoza
000165902 700__ $$0(orcid)0000-0003-0154-0730$$aPardo, J$$uUniversidad de Zaragoza
000165902 700__ $$aBrosch, R
000165902 700__ $$0(orcid)0000-0003-2993-5478$$aMartin, C$$uUniversidad de Zaragoza
000165902 7102_ $$11008$$2630$$aUniversidad de Zaragoza$$bDpto. Microb.Med.Pr.,Sal.Públ.$$cÁrea Microbiología
000165902 7102_ $$11009$$2773$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Sanidad Animal
000165902 7102_ $$11008$$2566$$aUniversidad de Zaragoza$$bDpto. Microb.Med.Pr.,Sal.Públ.$$cÁrea Inmunología
000165902 7102_ $$11008$$2X$$aUniversidad de Zaragoza$$bDpto. Microb.Med.Pr.,Sal.Públ.$$cProy. investigación HQA
000165902 7102_ $$11002$$2060$$aUniversidad de Zaragoza$$bDpto. Bioq.Biolog.Mol. Celular$$cÁrea Bioquímica y Biolog.Mole.
000165902 773__ $$g15, 12 (2013), 1994-2005$$pCell. microbiol.$$tCELLULAR MICROBIOLOGY$$x1462-5814
000165902 8564_ $$s1195135$$uhttps://zaguan.unizar.es/record/165902/files/texto_completo.pdf$$yPostprint
000165902 8564_ $$s1127799$$uhttps://zaguan.unizar.es/record/165902/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000165902 909CO $$ooai:zaguan.unizar.es:165902$$particulos$$pdriver
000165902 951__ $$a2026-01-15-21:56:12
000165902 980__ $$aARTICLE