000165909 001__ 165909
000165909 005__ 20260116002211.0
000165909 0247_ $$2doi$$a10.1126/sciimmunol.abc2934
000165909 0248_ $$2sideral$$a126402
000165909 037__ $$aART-2021-126402
000165909 041__ $$aeng
000165909 100__ $$aMata, E.$$uUniversidad de Zaragoza
000165909 245__ $$aPulmonary BCG induces lung-resident macrophage activation and confers long-term protection against tuberculosis
000165909 260__ $$c2021
000165909 5203_ $$aBacillus Calmette-Guerin (BCG) is an attenuated bacterial vaccine used to protect against Mycobacterium tuberculosis (Mtb) in regions where infections are highly prevalent. BCG is currently delivered by the intradermal route, but alternative routes of administration are of great interest, including intrapulmonary delivery to more closely mimic respiratory Mtb infection. In this study, mice subjected to pulmonary delivery of green fluorescent protein-tagged strains of virulent (Mtb) and attenuated (BCG) mycobacteria were studied to better characterize infected lung cell subsets. Profound differences in dissemination patterns were detected between Mtb and BCG, with a strong tendency of Mtb to disseminate from alveolar macrophages (AMs) to other myeloid subsets, mainly neutrophils and recruited macrophages. BCG mostly remained in AMs, which promoted their activation. These preactivated macrophages were highly efficient in containing Mtb bacilli upon challenge and disrupting early bacterial dissemination, which suggests a potential mechanism of protection associated with pulmonary BCG vaccination. Respiratory BCG also protected mice against a lethal Streptococcus pneumoniae challenge, suggesting that BCG-induced innate activation could confer heterologous protection against respiratory pathogens different from Mtb. BCG drove long-term activation of AMs, even after vaccine clearance, and these AMs reacted efficiently upon subsequent challenge. These results suggest the generation of a trained innate memory-like response in AMs induced by pulmonary BCG vaccination.
000165909 536__ $$9info:eu-repo/grantAgreement/ES/DGA-FEDER/Construyendo Europa desde Aragón$$9info:eu-repo/grantAgreement/ES/MCIU/RTI2018-097625-B-I00
000165909 540__ $$9info:eu-repo/semantics/closedAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000165909 590__ $$a30.658$$b2021
000165909 591__ $$aIMMUNOLOGY$$b5 / 162 = 0.031$$c2021$$dQ1$$eT1
000165909 592__ $$a11.962$$b2021
000165909 593__ $$aImmunology and Allergy$$c2021$$dQ1
000165909 593__ $$aImmunology$$c2021$$dQ1
000165909 594__ $$a25.5$$b2021
000165909 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000165909 700__ $$0(orcid)0000-0002-3086-3013$$aTarancon, R.
000165909 700__ $$0(orcid)0000-0002-7963-7797$$aGuerrero, C.$$uUniversidad de Zaragoza
000165909 700__ $$0(orcid)0000-0002-0182-201X$$aMoreo, E.$$uUniversidad de Zaragoza
000165909 700__ $$aMoreau, F.
000165909 700__ $$0(orcid)0000-0001-7866-2803$$aUranga, S.$$uUniversidad de Zaragoza
000165909 700__ $$0(orcid)0000-0002-9713-2127$$aGomez, A.B.$$uUniversidad de Zaragoza
000165909 700__ $$0(orcid)0000-0001-8644-120X$$aMarinova, D.$$uUniversidad de Zaragoza
000165909 700__ $$aDomenech, M.
000165909 700__ $$aGonzalez-Camacho, F.
000165909 700__ $$0(orcid)0000-0002-2787-9671$$aMonzon, M.$$uUniversidad de Zaragoza
000165909 700__ $$0(orcid)0000-0002-7173-7216$$aBadiola, J.$$uUniversidad de Zaragoza
000165909 700__ $$aDominguez-Andres, J.
000165909 700__ $$aYuste, J
000165909 700__ $$0(orcid)0000-0002-5175-8394$$aAnel, A.$$uUniversidad de Zaragoza
000165909 700__ $$0(orcid)0000-0003-2993-5478$$aPeixoto, A.$$uUniversidad de Zaragoza
000165909 700__ $$aMartin, C.
000165909 700__ $$aAguilo, N.
000165909 7102_ $$11011$$2630$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Microbiología
000165909 7102_ $$11003$$2443$$aUniversidad de Zaragoza$$bDpto. Anatom.Histolog.Humanas$$cArea Histología
000165909 7102_ $$11009$$2773$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Sanidad Animal
000165909 7102_ $$11011$$2X$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cProy. investigación HQA
000165909 7102_ $$11002$$2060$$aUniversidad de Zaragoza$$bDpto. Bioq.Biolog.Mol. Celular$$cÁrea Bioquímica y Biolog.Mole.
000165909 773__ $$g6, 63 (2021)$$pSci. immunol.$$tScience Immunology$$x2470-9468
000165909 8564_ $$s4166305$$uhttps://zaguan.unizar.es/record/165909/files/texto_completo.pdf$$yVersión publicada
000165909 8564_ $$s3434750$$uhttps://zaguan.unizar.es/record/165909/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000165909 909CO $$ooai:zaguan.unizar.es:165909$$particulos$$pdriver
000165909 951__ $$a2026-01-15-21:56:23
000165909 980__ $$aARTICLE