000165982 001__ 165982
000165982 005__ 20260116163026.0
000165982 0247_ $$2doi$$a10.1016/j.amjoto.2022.103771
000165982 0248_ $$2sideral$$a136530
000165982 037__ $$aART-2023-136530
000165982 041__ $$aeng
000165982 100__ $$aGalindo Torres, Blanca Pilar
000165982 245__ $$aKnowledge and expectations about miRNAs as biomarkers in head and neck squamous cell cancers
000165982 260__ $$c2023
000165982 5203_ $$aHead and neck squamous cell cancer patients suffer from a high postoperative recurrence rate and poor prognosis. Thus, it is essential to better understand the underlying molecular mechanisms and identify the role of new biomarkers. Recent research has shown that the dysregulation of microRNAs is a potential biomarker as a screening or prognostic tool. Moreover, the literature reveals its promising usefulness to select the best treatment strategy and monitor tumour response. The purpose of this review is to identify and synthesize the available literature on microRNAs as biomarkers that could help manage patients with head and neck squamous cell cancer. A search in scientific databases was completed, including all relevant articles related to circulating microRNAs in head and neck squamous cell cancer published in English or Spanish. We focused on articles whose main findings were related to their usefulness in diagnosis and prognosis. Conclusion: Knowledge of microRNAs opens the possibilities that these molecules offer in terms of monitoring cancer disease in a less-invasive, simple manner, allowing for serial sampling to assess the response to treatment and minimal residual disease. It is yet to be determined whether liquid biopsy will replace the traditional biopsy in the future but it represents a change in the paradigm of management of head and neck squamous cell cancer.
000165982 540__ $$9info:eu-repo/semantics/closedAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000165982 590__ $$a1.8$$b2023
000165982 591__ $$aOTORHINOLARYNGOLOGY$$b24 / 66 = 0.364$$c2023$$dQ2$$eT2
000165982 592__ $$a0.648$$b2023
000165982 593__ $$aOtorhinolaryngology$$c2023$$dQ2
000165982 594__ $$a4.4$$b2023
000165982 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000165982 700__ $$aGarcía Girón, Carlos
000165982 700__ $$aAlcaraz Ortega, Raquel
000165982 700__ $$aSaiz López, Patricia
000165982 700__ $$0(orcid)0000-0002-3265-504X$$aAdiego Leza, María Isabel$$uUniversidad de Zaragoza
000165982 700__ $$aGrijalba Uche, Miguel Víctor
000165982 7102_ $$11013$$2653$$aUniversidad de Zaragoza$$bDpto. Cirugía$$cÁrea Otorrinolaringología
000165982 773__ $$g44, 2 (2023), 103771 [7 pp.]$$pAm. j. otolaryngol.$$tAMERICAN JOURNAL OF OTOLARYNGOLOGY$$x0196-0709
000165982 8564_ $$s431460$$uhttps://zaguan.unizar.es/record/165982/files/texto_completo.pdf$$yVersión publicada
000165982 8564_ $$s2443797$$uhttps://zaguan.unizar.es/record/165982/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000165982 909CO $$ooai:zaguan.unizar.es:165982$$particulos$$pdriver
000165982 951__ $$a2026-01-16-14:54:11
000165982 980__ $$aARTICLE