165982 20260119151008.0 doi 10.1016/j.amjoto.2022.103771 sideral 136530 ART-2023-136530 eng Galindo Torres, Blanca Pilar Knowledge and expectations about miRNAs as biomarkers in head and neck squamous cell cancers 2023 Head and neck squamous cell cancer patients suffer from a high postoperative recurrence rate and poor prognosis. Thus, it is essential to better understand the underlying molecular mechanisms and identify the role of new biomarkers. Recent research has shown that the dysregulation of microRNAs is a potential biomarker as a screening or prognostic tool. Moreover, the literature reveals its promising usefulness to select the best treatment strategy and monitor tumour response. The purpose of this review is to identify and synthesize the available literature on microRNAs as biomarkers that could help manage patients with head and neck squamous cell cancer. A search in scientific databases was completed, including all relevant articles related to circulating microRNAs in head and neck squamous cell cancer published in English or Spanish. We focused on articles whose main findings were related to their usefulness in diagnosis and prognosis. Conclusion: Knowledge of microRNAs opens the possibilities that these molecules offer in terms of monitoring cancer disease in a less-invasive, simple manner, allowing for serial sampling to assess the response to treatment and minimal residual disease. It is yet to be determined whether liquid biopsy will replace the traditional biopsy in the future but it represents a change in the paradigm of management of head and neck squamous cell cancer. info:eu-repo/semantics/closedAccess All rights reserved http://www.europeana.eu/rights/rr-f/ 1.8 2023 OTORHINOLARYNGOLOGY 24 / 66 = 0.364 2023 Q2 T2 0.648 2023 Otorhinolaryngology 2023 Q2 4.4 2023 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion García Girón, Carlos Alcaraz Ortega, Raquel Saiz López, Patricia Adiego Leza, María Isabel Universidad de Zaragoza (orcid)0000-0002-3265-504X Grijalba Uche, Miguel Víctor 1013 653 Universidad de Zaragoza Dpto. Cirugía Área Otorrinolaringología 44, 2 (2023), 103771 [7 pp.] Am. j. otolaryngol. AMERICAN JOURNAL OF OTOLARYNGOLOGY 0196-0709 431460 http://zaguan.unizar.es/record/165982/files/texto_completo.pdf Versión publicada 2443797 http://zaguan.unizar.es/record/165982/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:165982 articulos driver 2026-01-19-15:09:32 ARTICLE