000166041 001__ 166041
000166041 005__ 20260119170325.0
000166041 0247_ $$2doi$$a10.1016/j.clnu.2021.04.036
000166041 0248_ $$2sideral$$a127262
000166041 037__ $$aART-2021-127262
000166041 041__ $$aeng
000166041 100__ $$0(orcid)0000-0003-4242-5464$$aIguacel, I.$$uUniversidad de Zaragoza
000166041 245__ $$aAssociations between dietary amino acid intakes and blood concentration levels
000166041 260__ $$c2021
000166041 5060_ $$aAccess copy available to the general public$$fUnrestricted
000166041 5203_ $$aBackground and aims: Emerging evidence suggests a role of amino acids (AAs) in the development of various diseases including renal failure, liver cirrhosis, diabetes and cancer. However, mechanistic pathways and the effects of dietary AA intakes on circulating levels and disease outcomes are unclear. We aimed to compare protein and AA intakes, with their respective blood concentrations in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.
Methods: Dietary protein and AA intakes were assessed via the EPIC dietary questionnaires (DQ) and 24-h dietary recalls (24-HDR). A subsample of 3768 EPIC participants who were free of cancer had blood AA concentrations measured. To investigate how circulating levels relate to their respective intakes, dietary AA intake was examined in quintiles and ANOVA tests were run. Pearson correlations were examined for continous associations between intakes and blood concentrations.
Results: Dietary AA intakes (assessed with the DQ) and blood AA concentrations were not strongly correlated (-0.15 = r = 0.17) and the direction of the correlations depended on AA class: weak positive correlations were found for most essential AAs (isoleucine, leucine, lysine, methionine, threonine, tryptophan, and valine) and conditionally essential AAs (arginine and tyrosine), while negative associations were found for non-essential AAs. Similar results were found when using the 24-HDR. When conducting ANOVA tests for essential AAs, higher intake quintiles were linked to higher blood AA concentrations, except for histidine and phenylalanine. For non-essential AAs and glycine, an inverse relationship was observed. Conditionally-essential AAs showed mixed results.
Conclusions: Weak positive correlations and dose responses were found between most essential and conditionally essential AA intakes, and blood concentrations, but not for the non-essential AAs. These results suggest that intake of dietary AA might be related to physiological AA status, particularly for the essential AAs. However, these results should be further evaluated and confirmed in large-scale prospective studies.
000166041 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
000166041 590__ $$a7.643$$b2021
000166041 591__ $$aNUTRITION & DIETETICS$$b13 / 90 = 0.144$$c2021$$dQ1$$eT1
000166041 592__ $$a1.553$$b2021
000166041 593__ $$aNutrition and Dietetics$$c2021$$dQ1
000166041 593__ $$aCritical Care and Intensive Care Medicine$$c2021$$dQ1
000166041 594__ $$a9.9$$b2021
000166041 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000166041 700__ $$aSchmidt, J.A.
000166041 700__ $$aPerez-Cornago, A.
000166041 700__ $$aVan Puyvelde, H.
000166041 700__ $$aTravis, R.
000166041 700__ $$aStepien, M.
000166041 700__ $$aScalbert, A.
000166041 700__ $$aCasagrande, C.
000166041 700__ $$aWeiderpass, E.
000166041 700__ $$aRiboli, E.
000166041 700__ $$aSchulze, M.B.
000166041 700__ $$aSkeie, G.
000166041 700__ $$aBodén, S.
000166041 700__ $$aBoeing, H.
000166041 700__ $$aCross, A.J.
000166041 700__ $$aHarlid, S.
000166041 700__ $$aJensen, T.E.
000166041 700__ $$aHuerta, J.M.
000166041 700__ $$aKatzke, V.
000166041 700__ $$aKühn, T.
000166041 700__ $$aLujan-Barroso, L.
000166041 700__ $$aMasala, G.
000166041 700__ $$aRodriguez-Barranco, M.
000166041 700__ $$aRostgaard-Hansen, A.L.
000166041 700__ $$aVan der Schouw, Y.T.
000166041 700__ $$aVermeulen, R.
000166041 700__ $$aTagliabue, G.
000166041 700__ $$aTjønneland, A.
000166041 700__ $$aTrevisan, M.
000166041 700__ $$aFerrari, P.
000166041 700__ $$aGunter, M.J.
000166041 700__ $$aHuybrechts, I.
000166041 7102_ $$11006$$2255$$aUniversidad de Zaragoza$$bDpto. Fisiatría y Enfermería$$cÁrea Enfermería
000166041 773__ $$g40, 6 (2021), 3772-3779$$pClin. nutr.$$tClinical Nutrition$$x0261-5614
000166041 8564_ $$s884216$$uhttps://zaguan.unizar.es/record/166041/files/texto_completo.pdf$$yPostprint
000166041 8564_ $$s1417429$$uhttps://zaguan.unizar.es/record/166041/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000166041 909CO $$ooai:zaguan.unizar.es:166041$$particulos$$pdriver
000166041 951__ $$a2026-01-19-14:38:46
000166041 980__ $$aARTICLE