166047 20260119170325.0 doi 10.1016/j.chemosphere.2022.135473 sideral 129810 ART-2022-129810 eng Pino-Otín, María Rosa Impact of eight widely consumed antibiotics on the growth and physiological profile of natural soil microbial communities 2022 Antibiotics’ (ATBs) occurrence in soil ecosystems has a relevant effect in the structure and functionality of edaphic microbial communities, mainly because of their amendment with manure and biosolids that alter their key ecological functions. In this study, the impact of eight widely consumed ATBs on a natural soil microbial community, characterized through 16 S rRNA gene sequencing, was evaluated. Changes induced by the ATBs in the growth of the soil microbiota and in the community-level physiological profiling (CLPP), using Biolog EcoPlates™, were measured as endpoint. The eight assayed ATBs lead to a significant decrease in the growth of soil microbial communities in a dose-dependent way, ordered by its effect as follows: chloramphenicol > gentamycin > erythromycin > ampicillin > penicillin > amoxicillin > tetracycline > streptomycin. Chloramphenicol, gentamycin, and erythromycin adversely affected the physiological profile of the soil community, especially its ability to metabolize amino acids, carboxylic and ketonic acids and polymers. The analysis of the relationship between the physico-chemical properties of ATBs, as well as their mechanism of action, revealed that, except for the aminoglycosides, each ATB is influenced by a different physico-chemical parameters, even for ATBs of the same family. Significant effects were detected from 100 μg mL to 1, concentrations that can be found in digested sludge, biosolids and even in fertilized soils after repeated application of manure, so cumulative and long-term effects of these antibiotics on soil environment cannot be ruled out. Access copy available to the general public Unrestricted info:eu-repo/grantAgreement/ES/DGA/E39-20R info:eu-repo/semantics/openAccess by-nc-nd https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es 8.8 2022 ENVIRONMENTAL SCIENCES 30 / 275 = 0.109 2022 Q1 T1 1.727 2022 Chemistry (miscellaneous) 2022 Q1 Environmental Chemistry 2022 Q1 Environmental Engineering 2022 Q1 Public Health, Environmental and Occupational Health 2022 Q1 Medicine (miscellaneous) 2022 Q1 Pollution 2022 Q1 Health, Toxicology and Mutagenesis 2022 Q1 13.3 2022 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Ferrando, Natalia Ballestero, Diego Langa, Elisa Roig, Francisco J. Terrado, Eva M. Universidad de Zaragoza (orcid)0000-0001-8511-5218 4013 205 Universidad de Zaragoza Dpto. Didácticas Específicas Área Didáctica Ciencias Exper. 305 (2022), 135473 [12 pp] Chemosphere CHEMOSPHERE 0045-6535 2681645 http://zaguan.unizar.es/record/166047/files/texto_completo.pdf Postprint 1883341 http://zaguan.unizar.es/record/166047/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:166047 articulos driver 2026-01-19-14:38:54 ARTICLE