000166049 001__ 166049
000166049 005__ 20260119170325.0
000166049 0247_ $$2doi$$a10.1039/d3gc01669b
000166049 0248_ $$2sideral$$a134931
000166049 037__ $$aART-2023-134931
000166049 041__ $$aeng
000166049 100__ $$aZuriaga, Estefanía
000166049 245__ $$aEvaluation of the toxicity profiles of three families of solvents from biomass: levulinate, lactate and furfural derivatives
000166049 260__ $$c2023
000166049 5203_ $$aNowadays, the scientific community is looking for and developing new solvents, called green solvents, which, due to their physicochemical properties and their origin, can replace traditional solvents. Among the different types of these solvents are those derived from biomass, which seem to have properties suitable for Green Chemistry. In this study, a total of eleven solvents derived from biomass, divided into three families structurally related: levulinate, lactate and furfural, have been selected. For these solvents, the physicochemical and ecotoxicological properties have been previously studied; however, their toxicological profile is still poorly known. In this study, cytotoxicity is analyzed by exploring a wide range of biochemical pathways and changes in cell morphology, including different cell lines and an ex vivo model. Throughout the tests performed, it has been observed that most of the solvents in the furfural family have a higher toxicity profile than the rest of the solvents evaluated. In addition, many solvents, although not highly toxic, showed cellular morphological damage and stress responses that should be considered.
000166049 536__ $$9info:eu-repo/grantAgreement/ES/DGA/B44-23R$$9info:eu-repo/grantAgreement/ES/DGA/B58-23D$$9info:eu-repo/grantAgreement/ES/UZ/JIUZ-2021-BIO-08
000166049 540__ $$9info:eu-repo/semantics/closedAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000166049 590__ $$a9.3$$b2023
000166049 591__ $$aGREEN & SUSTAINABLE SCIENCE & TECHNOLOGY$$b14 / 91 = 0.154$$c2023$$dQ1$$eT1
000166049 591__ $$aCHEMISTRY, MULTIDISCIPLINARY$$b32 / 231 = 0.139$$c2023$$dQ1$$eT1
000166049 592__ $$a1.878$$b2023
000166049 593__ $$aPollution$$c2023$$dQ1
000166049 593__ $$aEnvironmental Chemistry$$c2023$$dQ1
000166049 594__ $$a16.1$$b2023
000166049 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000166049 700__ $$aLomba, Laura
000166049 700__ $$aGarcía, Cristina B.
000166049 700__ $$0(orcid)0000-0002-2231-7565$$aValero, Marta Sofia$$uUniversidad de Zaragoza
000166049 7102_ $$11012$$2410$$aUniversidad de Zaragoza$$bDpto. Farmac.Fisiol.y Med.L.F.$$cÁrea Fisiología
000166049 773__ $$g25, 18 (2023), 7344-7355$$pGreen chem.$$tGREEN CHEMISTRY$$x1463-9262
000166049 8564_ $$s858218$$uhttps://zaguan.unizar.es/record/166049/files/texto_completo.pdf$$yVersión publicada
000166049 8564_ $$s2208556$$uhttps://zaguan.unizar.es/record/166049/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000166049 909CO $$ooai:zaguan.unizar.es:166049$$particulos$$pdriver
000166049 951__ $$a2026-01-19-14:38:58
000166049 980__ $$aARTICLE