000166114 001__ 166114 000166114 005__ 20260120151004.0 000166114 0247_ $$2doi$$a10.1016/j.cpcardiol.2025.103218 000166114 0248_ $$2sideral$$a147507 000166114 037__ $$aART-2025-147507 000166114 041__ $$aeng 000166114 100__ $$aEchevarría-Polo, Marcos$$uUniversidad de Zaragoza 000166114 245__ $$aEffects of concurrent training on atrial fibrillation burden, fitness and physical activity after pulmonary vein isolation: Study protocol for a randomized controlled trial 000166114 260__ $$c2025 000166114 5203_ $$aBackground: Pulmonary vein isolation (PVI) is an effective treatment for atrial fibrillation (AF), but many patients remain inactive after the procedure for fear of AF recurrence. Evidence supports moderate exercise to improve outcomes of this procedure; however, there are no clear guidelines for returning to physical exercise after PVI. We aim to evaluate the effects of a combined endurance and resistance training (CT) intervention on cardiac function, physical fitness, activity levels, body composition, quality of life, and AF burden after PVI. Methods and results: We will conduct a randomized controlled trial with 68 participants, approximately 15 months after PVI, randomized 1:1 to a CT or control group. The CT program consists of supervised training sessions combining moderate-intensity endurance and resistance work three times a week for 12 weeks. Outcomes will be assessed at three time points: at baseline, after the intervention, and after 12 weeks of follow-up, including echocardiographic and electrocardiographic parameters, fitness tests, physical activity monitoring, body composition, health-related quality of life, and AF burden monitored by an implantable cardiac Holter. We expect that CT intervention will improve cardiac function, increase physical fitness and activity levels, optimize body composition, and improve quality of life without recurrence of AF. Conclusions: This protocol is the first to examine the effects of return to exercise training in AF patients after PVI using objective monitoring tools. The simplicity and scalability of the intervention support its safe integration into clinical practice to promote physical activity and improve patient outcomes after PVI. 000166114 536__ $$9info:eu-repo/grantAgreement/ES/DGA/T39-23R$$9info:eu-repo/grantAgreement/ES/MICINN/PID2022-140556OB-I00$$9info:eu-repo/grantAgreement/EUR/MICINN/TED2021-130459B-I00 000166114 540__ $$9info:eu-repo/semantics/closedAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/ 000166114 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000166114 700__ $$0(orcid)0000-0001-6025-5070$$aHernández-Vicente, Adrián$$uUniversidad de Zaragoza 000166114 700__ $$aVadillo-Martín, Pablo 000166114 700__ $$aSanchis-Gomar, Fabian 000166114 700__ $$aMelero-Polo, Jorge$$uUniversidad de Zaragoza 000166114 700__ $$aCabrera-Ramos, Mercedes$$uUniversidad de Zaragoza 000166114 700__ $$aMontilla-Padilla, Isabel$$uUniversidad de Zaragoza 000166114 700__ $$aRucco, Andrea$$uUniversidad de Zaragoza 000166114 700__ $$0(orcid)0000-0002-7503-3339$$aMartínez, Juan Pablo$$uUniversidad de Zaragoza 000166114 700__ $$0(orcid)0000-0003-3434-9254$$aLaguna, Pablo$$uUniversidad de Zaragoza 000166114 700__ $$0(orcid)0000-0002-1960-407X$$aPueyo, Esther$$uUniversidad de Zaragoza 000166114 700__ $$aRamos-Maqueda, Javier$$uUniversidad de Zaragoza 000166114 700__ $$0(orcid)0000-0001-8374-9081$$aGaratachea, Nuria$$uUniversidad de Zaragoza 000166114 7102_ $$11006$$2245$$aUniversidad de Zaragoza$$bDpto. Fisiatría y Enfermería$$cÁrea Educación Física y Depor. 000166114 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina 000166114 7102_ $$15008$$2800$$aUniversidad de Zaragoza$$bDpto. Ingeniería Electrón.Com.$$cÁrea Teoría Señal y Comunicac. 000166114 773__ $$g51, 3 (2025), 103218 [11 pp.]$$pCurr. probl. cardiol.$$tCURRENT PROBLEMS IN CARDIOLOGY$$x0146-2806 000166114 8564_ $$s3061738$$uhttps://zaguan.unizar.es/record/166114/files/texto_completo.pdf$$yVersión publicada$$zinfo:eu-repo/date/embargoEnd/2026-11-27 000166114 8564_ $$s1981570$$uhttps://zaguan.unizar.es/record/166114/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada$$zinfo:eu-repo/date/embargoEnd/2026-11-27 000166114 909CO $$ooai:zaguan.unizar.es:166114$$particulos$$pdriver 000166114 951__ $$a2026-01-20-14:17:55 000166114 980__ $$aARTICLE