000167842 001__ 167842
000167842 005__ 20260121151418.0
000167842 0247_ $$2doi$$a10.1016/j.smallrumres.2019.05.014
000167842 0248_ $$2sideral$$a112414
000167842 037__ $$aART-2019-112414
000167842 041__ $$aeng
000167842 100__ $$0(orcid)0000-0002-0313-5926$$aOrtín, A.$$uUniversidad de Zaragoza
000167842 245__ $$aOvine pulmonary adenocarcinoma: A transmissible lung cancer of sheep, difficult to control
000167842 260__ $$c2019
000167842 5203_ $$aOvine pulmonary adenocarcinoma (OPA) is a contagious lung cancer of sheep caused by jaagsiekte sheep retrovirus (JSRV), which induces the transformation of secretory epithelial cells of the distal respiratory tract. The disease has been recorded in the major sheep rearing areas with the exceptions of Australia and New Zealand, and is clinically characterized by a chronic respiratory process that often involves the production of pulmonary fluid that is discharged from the nostrils in final stages of the disease while the “wheelbarrow” test is performed. The respiratory route has been accepted to be the most important natural mode of transmission for JSRV but colostrum and milk can transmit JSRV to lambs. In OPA affected flocks, under endemic conditions, JSRV infected sheep may be present in a high proportion but very few of them develop clinical signs. Such apparently healthy animals are responsible for the spread of the disease because is difficult to identify infected animals or preclinical stages. There are not serological diagnostic tests due to the lack of a detectable immune response in JSRV infected animals, and although blood molecular tests are available their sensitivity is low. For this reason the disease has failed to be controlled so far and continues to cause significant economic losses. Control strategies based on colostrum and milk management have been demonstrated to be effective but expensive for most commercial flocks. In the recent years efforts for controlling the disease have focussed on searching methods for early diagnosis and the next future seems to be the establishment of low risk status for OPA in the flocks. Nevertheless, working on improving the identification of infected animals is essential for the implementation of effective strategies for OPA eradication.
000167842 540__ $$9info:eu-repo/semantics/closedAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000167842 590__ $$a1.273$$b2019
000167842 591__ $$aAGRICULTURE, DAIRY & ANIMAL SCIENCE$$b34 / 63 = 0.54$$c2019$$dQ3$$eT2
000167842 592__ $$a0.568$$b2019
000167842 593__ $$aFood Animals$$c2019$$dQ2
000167842 593__ $$aAnimal Science and Zoology$$c2019$$dQ2
000167842 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000167842 700__ $$0(orcid)0000-0003-3792-287X$$aDe las Heras, M.$$uUniversidad de Zaragoza
000167842 700__ $$0(orcid)0000-0002-0680-9957$$aBorobia, M.$$uUniversidad de Zaragoza
000167842 700__ $$0(orcid)0000-0002-6282-5038$$aRamo, M.A.$$uUniversidad de Zaragoza
000167842 700__ $$aOrtega, M.
000167842 700__ $$0(orcid)0000-0002-7655-2472$$aRuíz de Arcaute, M.$$uUniversidad de Zaragoza
000167842 7102_ $$11009$$2773$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Sanidad Animal
000167842 7102_ $$11009$$2617$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Medicina y Cirugía Animal
000167842 773__ $$g176 (2019), 37-41$$pSmall rumin. res.$$tSmall Ruminant Research$$x0921-4488
000167842 8564_ $$s1033520$$uhttps://zaguan.unizar.es/record/167842/files/texto_completo.pdf$$yVersión publicada
000167842 8564_ $$s2579753$$uhttps://zaguan.unizar.es/record/167842/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000167842 909CO $$ooai:zaguan.unizar.es:167842$$particulos$$pdriver
000167842 951__ $$a2026-01-21-14:54:41
000167842 980__ $$aARTICLE