000167846 001__ 167846
000167846 005__ 20260121151419.0
000167846 0247_ $$2doi$$a10.1159/000549499
000167846 0248_ $$2sideral$$a147534
000167846 037__ $$aART-2025-147534
000167846 041__ $$aeng
000167846 100__ $$aWiedemann, Urs C.H.
000167846 245__ $$aEarly-Onset of obesity model: impact of early-onset obesity on comorbidity risk and life expectancy
000167846 260__ $$c2025
000167846 5060_ $$aAccess copy available to the general public$$fUnrestricted
000167846 5203_ $$aIntroduction. Early-onset obesity increases the risk of developing comorbidities and decreases life expectancy with many variables such as age of onset, severity, and duration of obesity each having an individual influence. Here, we present findings from a model that aims to assess the impact of early-onset obesity. Methods The Early-Onset Obesity Model (EOObesity Model) was built by integrating data from clinical studies with demographic information. It categorizes information into four primary groups: prevalence, morbidity risk, mortality risk, and impact of obesity duration. Type 2 diabetes, cardiovascular events (fatal and non-fatal events, cardiovascular disease, and coronary heart disease), metabolic dysfunction-associated steatotic liver disease, asthma, obstructive sleep apnea, and cancer were evaluated over a range of age and body mass index (BMI) z-scores. Results The EOObesity Model provides a systematic approach for estimating the impact of early-onset obesity on risk of comorbidities and on life expectancy by considering individual patient weight trajectories. We test different scenarios to illustrate the potential impact of age of onset and severity of obesity on the risk of various comorbidities, on life expectancy, and on disability-adjusted life years. The model indicates that severe early-onset obesity has a high impact on life expectancy with, for example, up to 42 years of life lost if a patient has a BMI z-score of 4 by the age of 4 years. Discussion The model and these scenarios underscore the predicted substantially detrimental effects of early-onset and prolonged obesity on life expectancy, and the increased risks of obesity-related comorbidities. They suggest that morbidity and mortality risks increase with obesity duration and severity in a nonlinear manner, thereby supporting the view that early weight loss intervention and obesity prevention strategies may reduce long-term health risks substantially.
000167846 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc$$uhttps://creativecommons.org/licenses/by-nc/4.0/deed.es
000167846 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000167846 700__ $$avan den Akker, Erica L.T.
000167846 700__ $$aBarber, Thomas M.
000167846 700__ $$aClément, Karine
000167846 700__ $$aFarooqi, Sadaf
000167846 700__ $$aGoldstone, Anthony P.
000167846 700__ $$aHaqq, Andrea M.
000167846 700__ $$aMarcus, Claude
000167846 700__ $$aMolnár, Dénes
000167846 700__ $$0(orcid)0000-0003-0454-653X$$aMoreno, Luis A.$$uUniversidad de Zaragoza
000167846 700__ $$aNadler, Evan P.
000167846 700__ $$aPoitou, Christine
000167846 700__ $$aSchorfheide, Jan Luca
000167846 700__ $$aTouchot, Nicolas
000167846 700__ $$aWabitsch, Martin
000167846 700__ $$aKühnen, Peter
000167846 7102_ $$11006$$2255$$aUniversidad de Zaragoza$$bDpto. Fisiatría y Enfermería$$cÁrea Enfermería
000167846 773__ $$g(2025), [15 pp.]$$pObesity Facts$$tObesity Facts$$x1662-4025
000167846 8564_ $$s2779404$$uhttps://zaguan.unizar.es/record/167846/files/texto_completo.pdf$$yVersión publicada
000167846 8564_ $$s2103789$$uhttps://zaguan.unizar.es/record/167846/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000167846 909CO $$ooai:zaguan.unizar.es:167846$$particulos$$pdriver
000167846 951__ $$a2026-01-21-14:54:46
000167846 980__ $$aARTICLE