000167873 001__ 167873
000167873 005__ 20260121151420.0
000167873 0247_ $$2doi$$a10.1016/j.scp.2025.102070
000167873 0248_ $$2sideral$$a147545
000167873 037__ $$aART-2025-147545
000167873 041__ $$aeng
000167873 100__ $$aEsfahani, Mohammadreza Haftbaradaran$$uUniversidad de Zaragoza
000167873 245__ $$aGeraniol:l-menthol eutectic mixtures; thermophysical properties and drug solubility
000167873 260__ $$c2025
000167873 5060_ $$aAccess copy available to the general public$$fUnrestricted
000167873 5203_ $$aThe study of eco-sustainable alternative solvents as the eutectic mixtures (ESs) is a fundamental pillar of the concept of green chemistry. Furthermore, the dissolution of pharmaceutical active
ingredients (APIs) in ESs has shown to be a feasible strategy to improve the bioavailability of poorly soluble APIs in water. Here, three geraniol:l-menthol (GM) mixtures are characterized for
the first time. The structure and thermophysical properties were evaluated and discussed. Furthermore, the ability of GM ES and pure geraniol (G) to dissolve five APIs was determined and compared with that of water and other ESs. No similar studies were found in the literature for this system. From NMR, a more slowly diffusion of the species as the l-menthol ratio increased was observed. All hydrodynamic radii were similar, about 6.8 Å. Also, no strong aggregation was observed. At 298.15 K, the values of density, free volume, and surface tension were about 890 kg/m3, 72 %, and 28.5 mN/m, respectively. The dynamic viscosity ranged from 10 to 19 mPa s. These properties decreased as the G mole ratio increased. Furthermore, a parallel orientation of the adjacent dipoles was observed. Thermodynamic correlations and PC-SAFT equation of state were validated. The lowest solubility was obtained with water as solvent and the highest with pure G. Respectively, the values expressed as mole fraction of API were: 6.12⋅10− 6 and 2.31⋅10− 4 for nitrofurantoin, 4.17⋅10− 6 and 1.69⋅10− 3 for furosemide, 2.56⋅10− 8 and 0.028 for quercetin, 3.08⋅10− 5 and 0.026 for tetracycline, and 7.66⋅10− 7 and 0.042 for carvedilol.
000167873 536__ $$9info:eu-repo/grantAgreement/ES/DGA/E31-23R$$9info:eu-repo/grantAgreement/ES/NextGenerationEU/INVESTIGO-20-22
000167873 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
000167873 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000167873 700__ $$0(orcid)0000-0003-3641-1568$$aBergua, Fernando
000167873 700__ $$aDelso, Ignacio
000167873 700__ $$0(orcid)0000-0003-3632-6822$$aLafuente, Carlos$$uUniversidad de Zaragoza
000167873 700__ $$0(orcid)0000-0003-1810-9488$$aArtal, Manuela$$uUniversidad de Zaragoza
000167873 7102_ $$12012$$2755$$aUniversidad de Zaragoza$$bDpto. Química Física$$cÁrea Química Física
000167873 773__ $$g46 (2025), 102070 [22 pp.]$$tSustainable Chemistry and Pharmacy$$x2352-5541
000167873 8564_ $$s6112936$$uhttps://zaguan.unizar.es/record/167873/files/texto_completo.pdf$$yVersión publicada
000167873 8564_ $$s2030099$$uhttps://zaguan.unizar.es/record/167873/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000167873 909CO $$ooai:zaguan.unizar.es:167873$$particulos$$pdriver
000167873 951__ $$a2026-01-21-14:55:22
000167873 980__ $$aARTICLE