167873 20260121151420.0 doi 10.1016/j.scp.2025.102070 sideral 147545 ART-2025-147545 eng Esfahani, Mohammadreza Haftbaradaran Universidad de Zaragoza Geraniol:l-menthol eutectic mixtures; thermophysical properties and drug solubility 2025 The study of eco-sustainable alternative solvents as the eutectic mixtures (ESs) is a fundamental pillar of the concept of green chemistry. Furthermore, the dissolution of pharmaceutical active ingredients (APIs) in ESs has shown to be a feasible strategy to improve the bioavailability of poorly soluble APIs in water. Here, three geraniol:l-menthol (GM) mixtures are characterized for the first time. The structure and thermophysical properties were evaluated and discussed. Furthermore, the ability of GM ES and pure geraniol (G) to dissolve five APIs was determined and compared with that of water and other ESs. No similar studies were found in the literature for this system. From NMR, a more slowly diffusion of the species as the l-menthol ratio increased was observed. All hydrodynamic radii were similar, about 6.8 Å. Also, no strong aggregation was observed. At 298.15 K, the values of density, free volume, and surface tension were about 890 kg/m3, 72 %, and 28.5 mN/m, respectively. The dynamic viscosity ranged from 10 to 19 mPa s. These properties decreased as the G mole ratio increased. Furthermore, a parallel orientation of the adjacent dipoles was observed. Thermodynamic correlations and PC-SAFT equation of state were validated. The lowest solubility was obtained with water as solvent and the highest with pure G. Respectively, the values expressed as mole fraction of API were: 6.12⋅10− 6 and 2.31⋅10− 4 for nitrofurantoin, 4.17⋅10− 6 and 1.69⋅10− 3 for furosemide, 2.56⋅10− 8 and 0.028 for quercetin, 3.08⋅10− 5 and 0.026 for tetracycline, and 7.66⋅10− 7 and 0.042 for carvedilol. Access copy available to the general public Unrestricted info:eu-repo/grantAgreement/ES/DGA/E31-23R info:eu-repo/grantAgreement/ES/NextGenerationEU/INVESTIGO-20-22 info:eu-repo/semantics/openAccess by-nc-nd https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Bergua, Fernando (orcid)0000-0003-3641-1568 Delso, Ignacio Lafuente, Carlos Universidad de Zaragoza (orcid)0000-0003-3632-6822 Artal, Manuela Universidad de Zaragoza (orcid)0000-0003-1810-9488 2012 755 Universidad de Zaragoza Dpto. Química Física Área Química Física 46 (2025), 102070 [22 pp.] Sustainable Chemistry and Pharmacy 2352-5541 6112936 http://zaguan.unizar.es/record/167873/files/texto_completo.pdf Versión publicada 2030099 http://zaguan.unizar.es/record/167873/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:167873 articulos driver 2026-01-21-14:55:22 ARTICLE