000167900 001__ 167900
000167900 005__ 20260122111948.0
000167900 0247_ $$2doi$$a10.3390/ijms27010005
000167900 0248_ $$2sideral$$a147595
000167900 037__ $$aART-2026-147595
000167900 041__ $$aeng
000167900 100__ $$aGargallo-Alonso, Marta$$uUniversidad de Zaragoza
000167900 245__ $$aAdvances, mechanisms, and clinical perspectives for the in vitro maturation of human oocytes
000167900 260__ $$c2026
000167900 5060_ $$aAccess copy available to the general public$$fUnrestricted
000167900 5203_ $$aThe in vitro maturation (IVM) of human oocytes represents a valuable assisted reproductive technology that bypasses the need for full ovarian stimulation, offering safer alternatives for patients with polycystic ovary syndrome (PCOS), resistant ovary syndrome, or those requiring fertility preservation before oncological treatment. Despite its potential, IVM efficiency remains lower than that of conventional in vitro fertilization (IVF) due to incomplete understanding of the molecular and metabolic mechanisms underpinning oocyte maturation. This review summarizes recent advances in IVM, including biphasic or simulated physiological oocyte maturation (SPOM) systems, optimization of culture media through hormones, growth factors, and antioxidants, and the influence of cumulus–oocyte communication on developmental competence. We also discuss the biochemical regulation of meiosis, metabolic interactions, and gene expression patterns associated with oocyte quality. Furthermore, we examine the translational and clinical applications of IVM in human fertility treatment, highlighting its efficacy in PCOS and oncofertility cases, and the limitations that persist in replicating in vivo conditions. Emerging technologies such as microfluidic and three-dimensional culture systems show promise in enhancing oocyte competence and embryo yield. Continued research into the molecular mechanisms governing oocyte maturation will be key to improving IVM outcomes and integrating this approach as a mainstream option in reproductive medicine.
000167900 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es
000167900 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000167900 700__ $$aPicton, Helen M.
000167900 700__ $$aMalo, Clara$$uUniversidad de Zaragoza
000167900 7102_ $$11003$$2443$$aUniversidad de Zaragoza$$bDpto. Anatom.Histolog.Humanas$$cArea Histología
000167900 7102_ $$11009$$2617$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Medicina y Cirugía Animal
000167900 773__ $$g27, 1 (2026), 5 [22 pp.]$$pInt. j. mol. sci.$$tInternational Journal of Molecular Sciences$$x1661-6596
000167900 8564_ $$s1143563$$uhttps://zaguan.unizar.es/record/167900/files/texto_completo.pdf$$yVersión publicada
000167900 8564_ $$s2355642$$uhttps://zaguan.unizar.es/record/167900/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000167900 909CO $$ooai:zaguan.unizar.es:167900$$particulos$$pdriver
000167900 951__ $$a2026-01-22-10:27:04
000167900 980__ $$aARTICLE