000168022 001__ 168022
000168022 005__ 20260123152958.0
000168022 0247_ $$2doi$$a10.1016/j.ceramint.2025.11.127
000168022 0248_ $$2sideral$$a147633
000168022 037__ $$aART-2025-147633
000168022 041__ $$aeng
000168022 100__ $$aFelix, E.
000168022 245__ $$aPulsed laser ablation synthesis of thiol-functionalized W/Fe nanoparticles in liquid for MRI and CT imaging
000168022 260__ $$c2025
000168022 5203_ $$aNovel Thiol-functionalized tungsten iron oxide nanoparticles with potential applications as contrast agents in medical imaging have been obtained using scanning pulsed ablation in liquid. First, bulk ceramic targets of an orthorhombic (Pbcn) iron (III) tungstate phase type γ-Fe2WO6 with a tri-aPbO2 structure were prepared using a reaction-sintering method. Then, colloidal dispersions of nanoparticles were produced directly in both distilled water and ethanol by irradiating bulk γ-Fe2WO6 targets with high-power infrared nanosecond laser pulses. In addition, ex situ functionalization processes using glutathione or cysteamine as capping agents were applied, to enhance biocompatibility and colloidal stability at physiological pH values. A battery of techniques was used to characterize the γ-Fe2WO6 targets, the as-synthesized and the functionalized colloidal dispersions of W/Fe nanoparticles, including their composition, structure, magnetic properties, X-ray attenuation potential, biocompatibility and colloidal properties. The results indicate the successful formation of amorphous W/Fe nanoparticles using both distilled water or ethanol as the ablation medium, although only those synthesized in ethanol display a dominant ferromagnetic behavior, making them suitable for use as contrast agents in MRI. Moreover, nanoparticle colloidal dispersions synthesized in ethanol exhibit high X-ray attenuation. The linkage mechanism of functionalization was extensively studied to obtain information for subsequent bioconjugation. The formation of NPs with higher stability and proper functionalization occurs when cysteamine was used as a capping agent, although biocompatibility is better when using glutathione. Finally, functionalized W/Fe nanoparticles demonstrated good magnetic resonance imaging and X-ray computerized tomography imaging abilities, suggesting promising potential as dual-contrast agents.
000168022 536__ $$9info:eu-repo/grantAgreement/EC/H2020/656908/EU/Laser Induced Synthesis of Biocompatible Multifunctional Inorganic Nanoparticles: A Novel Route to Produce Multifunctional Contrast Agents for Early Diagnosis of Breast Cancer/NIMBLIS$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 656908-NIMBLIS$$9info:eu-repo/grantAgreement/EUR/MICIU/PID2023-150767OB-I00$$9info:eu-repo/grantAgreement/ES/MINECO/MAT2015-67354-R$$9info:eu-repo/grantAgreement/ES/MINECO/PID2020-118329RB-I00
000168022 540__ $$9info:eu-repo/semantics/closedAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000168022 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000168022 700__ $$aLitrán, R.
000168022 700__ $$aManuel, J.M.
000168022 700__ $$aRodríguez, M.A.
000168022 700__ $$aFernández-Ponce, C.
000168022 700__ $$aGarcía-Cózar, F.
000168022 700__ $$aYeste, M.P.
000168022 700__ $$0(orcid)0000-0003-4708-5577$$aLahoz, R.
000168022 700__ $$0(orcid)0000-0003-2553-0633$$aNatividad, E.$$uUniversidad de Zaragoza
000168022 700__ $$aGarcía-Villar, C.
000168022 700__ $$aLlaguno-Munive, M.
000168022 700__ $$aAbasolo, I.
000168022 700__ $$aPfaff, C.
000168022 700__ $$aKriwet, J.
000168022 700__ $$aBomati-Miguel, O.
000168022 7102_ $$15001$$2065$$aUniversidad de Zaragoza$$bDpto. Ciencia Tecnol.Mater.Fl.$$cÁrea Cienc.Mater. Ingen.Metal.
000168022 773__ $$g51, 30 (2025), 63399-63415$$pCeram. int.$$tCeramics International$$x0272-8842
000168022 8564_ $$s16832143$$uhttps://zaguan.unizar.es/record/168022/files/texto_completo.pdf$$yVersión publicada
000168022 8564_ $$s2318393$$uhttps://zaguan.unizar.es/record/168022/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000168022 909CO $$ooai:zaguan.unizar.es:168022$$particulos$$pdriver
000168022 951__ $$a2026-01-23-14:33:34
000168022 980__ $$aARTICLE