000168065 001__ 168065 000168065 005__ 20260205143931.0 000168065 0247_ $$2doi$$a10.1016/j.recesp.2016.10.018 000168065 0248_ $$2sideral$$a100939 000168065 037__ $$aART-2017-100939 000168065 041__ $$aspa 000168065 100__ $$aBea, Ana M. 000168065 245__ $$aAsociación de la presencia de placa carotídea en la aparición de eventos cardiovasculares en pacientes con hipercolesterolemias genéticas [Association Between the Presence of Carotid Artery Plaque and Cardiovascular Events in Patients With Genetic Hypercholesterolemia] 000168065 260__ $$c2017 000168065 5060_ $$aAccess copy available to the general public$$fUnrestricted 000168065 5203_ $$aIntroduction and objectives The equations used in the general population to calculate cardiovascular risk are not useful in genetic hypercholesterolemia (GH). Carotid plaque detection has proved useful in cardiovascular prediction and risk reclassification but there have been no studies of its usefulness in GH. The aim of this study was to determine the association between the presence of carotid artery plaque and the occurrence of cardiovascular events in patients with GH. Methods This study included 1778 persons with GH. The mean follow-up until the occurrence of cardiovascular events was 6.26 years. At presentation, the presence of carotid artery plaque was studied by high-resolution ultrasound. Results Carotid artery plaque was found in 661 (37.2%) patients: 31.9% with familial hypercholesterolemia, 39.8% with familial combined hyperlipidemia, 45.5% with dysbetalipoproteinemia, and 43.2% with polygenic hypercholesterolemia. During follow-up, 58 patients had a cardiovascular event. Event rates were 6354/100 000 (95%CI, 4432.4-8275.6) in the group with plaque and 1432/100 000 (95%CI, 730.6-2134.3) in the group without plaque, with significant differences between the 2 groups (P <.001). The relative risk of an event was 4.34 (95CI%, 2.44-7.71; P <.001) times higher in patients with plaque and was 2.40 (95%CI, 1.27-4.56; P =.007) times higher after adjustment for major risk factors. The number of carotid artery plaques was positively associated with the risk of cardiovascular events. Conclusions Most cardiovascular events occur in a subgroup of patients who can be identified by carotid plaque detection. These results support the use of plaque screening in this population and should help in risk stratification and treatment in GH. Full English text available from: www.revespcardiol.org/en 000168065 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII/RD12-0042-0055$$9info:eu-repo/grantAgreement/ES/MINECO/PI12-01087$$9info:eu-repo/grantAgreement/ES/MINECO/PI12-01321$$9info:eu-repo/grantAgreement/ES/MINECO/PI12-01703 000168065 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es 000168065 590__ $$a5.166$$b2017 000168065 591__ $$aCARDIAC & CARDIOVASCULAR SYSTEMS$$b26 / 128 = 0.203$$c2017$$dQ1$$eT1 000168065 592__ $$a0.553$$b2017 000168065 593__ $$aCardiology and Cardiovascular Medicine$$c2017$$dQ2 000168065 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion 000168065 700__ $$0(orcid)0000-0001-7043-0952$$aCiveira, Fernando$$uUniversidad de Zaragoza 000168065 700__ $$0(orcid)0000-0001-9142-0737$$aJarauta, Estíbaliz$$uUniversidad de Zaragoza 000168065 700__ $$0(orcid)0000-0002-9647-0108$$aLamiquiz-Moneo, Itziar. 000168065 700__ $$0(orcid)0000-0002-1894-1621$$aPérez-Calahorra, Sofía 000168065 700__ $$aMarco-Benedí, Victoria 000168065 700__ $$aCenarro, Ana 000168065 700__ $$0(orcid)0000-0001-6650-8294$$aMateo-Gallego, Rocío$$uUniversidad de Zaragoza 000168065 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina 000168065 773__ $$g70, 7 (2017), 551-558$$pRev. esp. cardiol.$$tRevista Española de Cardiología$$x0300-8932 000168065 8564_ $$s1885474$$uhttps://zaguan.unizar.es/record/168065/files/texto_completo.pdf$$yPostprint 000168065 8564_ $$s1787154$$uhttps://zaguan.unizar.es/record/168065/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint 000168065 909CO $$ooai:zaguan.unizar.es:168065$$particulos$$pdriver 000168065 951__ $$a2026-02-05-14:38:52 000168065 980__ $$aARTICLE