168065 20260205143931.0 doi 10.1016/j.recesp.2016.10.018 sideral 100939 ART-2017-100939 spa Bea, Ana M. Asociación de la presencia de placa carotídea en la aparición de eventos cardiovasculares en pacientes con hipercolesterolemias genéticas [Association Between the Presence of Carotid Artery Plaque and Cardiovascular Events in Patients With Genetic Hypercholesterolemia] 2017 Access copy available to the general public Unrestricted Introduction and objectives The equations used in the general population to calculate cardiovascular risk are not useful in genetic hypercholesterolemia (GH). Carotid plaque detection has proved useful in cardiovascular prediction and risk reclassification but there have been no studies of its usefulness in GH. The aim of this study was to determine the association between the presence of carotid artery plaque and the occurrence of cardiovascular events in patients with GH. Methods This study included 1778 persons with GH. The mean follow-up until the occurrence of cardiovascular events was 6.26 years. At presentation, the presence of carotid artery plaque was studied by high-resolution ultrasound. Results Carotid artery plaque was found in 661 (37.2%) patients: 31.9% with familial hypercholesterolemia, 39.8% with familial combined hyperlipidemia, 45.5% with dysbetalipoproteinemia, and 43.2% with polygenic hypercholesterolemia. During follow-up, 58 patients had a cardiovascular event. Event rates were 6354/100 000 (95%CI, 4432.4-8275.6) in the group with plaque and 1432/100 000 (95%CI, 730.6-2134.3) in the group without plaque, with significant differences between the 2 groups (P <.001). The relative risk of an event was 4.34 (95CI%, 2.44-7.71; P <.001) times higher in patients with plaque and was 2.40 (95%CI, 1.27-4.56; P =.007) times higher after adjustment for major risk factors. The number of carotid artery plaques was positively associated with the risk of cardiovascular events. Conclusions Most cardiovascular events occur in a subgroup of patients who can be identified by carotid plaque detection. These results support the use of plaque screening in this population and should help in risk stratification and treatment in GH. Full English text available from: www.revespcardiol.org/en info:eu-repo/grantAgreement/ES/ISCIII/RD12-0042-0055 info:eu-repo/grantAgreement/ES/MINECO/PI12-01087 info:eu-repo/grantAgreement/ES/MINECO/PI12-01321 info:eu-repo/grantAgreement/ES/MINECO/PI12-01703 info:eu-repo/semantics/openAccess by-nc-nd https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es 5.166 2017 CARDIAC & CARDIOVASCULAR SYSTEMS 26 / 128 = 0.203 2017 Q1 T1 0.553 2017 Cardiology and Cardiovascular Medicine 2017 Q2 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Civeira, Fernando Universidad de Zaragoza (orcid)0000-0001-7043-0952 Jarauta, Estíbaliz Universidad de Zaragoza (orcid)0000-0001-9142-0737 Lamiquiz-Moneo, Itziar. (orcid)0000-0002-9647-0108 Pérez-Calahorra, Sofía (orcid)0000-0002-1894-1621 Marco-Benedí, Victoria Cenarro, Ana Mateo-Gallego, Rocío Universidad de Zaragoza (orcid)0000-0001-6650-8294 1007 610 Universidad de Zaragoza Dpto. Medicina, Psiqu. y Derm. Area Medicina 70, 7 (2017), 551-558 Rev. esp. cardiol. Revista Española de Cardiología 0300-8932 1885474 http://zaguan.unizar.es/record/168065/files/texto_completo.pdf Postprint 1787154 http://zaguan.unizar.es/record/168065/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:168065 articulos driver 2026-02-05-14:38:52 ARTICLE