168067 20260202145621.0 doi 10.1016/j.numecd.2010.10.011 sideral 131346 ART-2011-131346 eng Jarauta, E. (orcid)0000-0001-9142-0737 Carotid atherosclerosis and lipoprotein particle subclasses in familial hypercholesterolaemia and familial combined hyperlipidaemia 2011 Background and Aims: Familial hypercholesterolaemia (FH) and familial combined hyperlipidaemia (FCH) are common atherogenic disorders with great variability in cardiovascular disease (CVD). No direct atherosclerosis burden comparisons have been performed between FH and FCH in relation to lipoprotein particle distribution. Methods and Results: Risk factors and three measures of carotid intima-media thickness (IMT) in both sides were determined in 572 FH, 250 FCH and 200 controls. Lipoproteins were assessed by nuclear magnetic resonance (NMR) spectroscopy. Compared with controls, IMT measures were increased in FH and FCH. FCH had the highest adjusted mean–maximum IMT. FH had twice low-density lipoprotein (LDL) particles than controls, but similar LDL subclass size and distribution. FCH subjects also had increased LDL particles and the highest number of small LDL (1519 ± 731 nmol l−1 vs. 887 ± 784 nmol l−1 in FH and 545 ± 409 nmol l−1 in controls). Age, gender, cholesterol/high-density lipoprotein (HDL) ratio, smoking and systolic blood pressure were independently associated with IMT in FH (r2 = 0.38). The same variables, except cholesterol/HDL ratio, were associated with IMT in FCH (r2 = 0.40). Among NMR lipoproteins, only VLDL and chylomicrons increased IMT prediction in FCH by 0.8%. Conclusion: FH and FCH subjects show increased carotid atherosclerosis in relation to classical risk factors. Lipoprotein subclasses do not substantially contribute to IMT variability. info:eu-repo/semantics/closedAccess All rights reserved http://www.europeana.eu/rights/rr-f/ 3.731 2011 CARDIAC & CARDIOVASCULAR SYSTEMS 27 / 117 = 0.231 2011 Q1 T1 NUTRITION & DIETETICS 13 / 73 = 0.178 2011 Q1 T1 ENDOCRINOLOGY & METABOLISM 36 / 122 = 0.295 2011 Q2 T1 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Mateo-Gallego, R. Universidad de Zaragoza (orcid)0000-0001-6650-8294 Gilabert, R. Plana, N. Junyent, M. de Groot, E. Cenarro, A. Universidad de Zaragoza Masana, L. Ros, E. Civeira, F. Universidad de Zaragoza (orcid)0000-0001-7043-0952 1007 610 Universidad de Zaragoza Dpto. Medicina, Psiqu. y Derm. Area Medicina 22, 7 (2011), 591-597 NMCD, Nutr. Metab. Cardiovasc. Dis. Nutrition, Metabolism and Cardiovascular Diseases 0939-4753 219102 http://zaguan.unizar.es/record/168067/files/texto_completo.pdf Versión publicada 2025141 http://zaguan.unizar.es/record/168067/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:168067 articulos driver 2026-02-02-14:49:04 ARTICLE