000168077 001__ 168077
000168077 005__ 20260126155509.0
000168077 0247_ $$2doi$$a10.1016/j.athoracsur.2015.12.017
000168077 0248_ $$2sideral$$a145074
000168077 037__ $$aART-2016-145074
000168077 041__ $$aeng
000168077 100__ $$0(orcid)0000-0003-0249-3104$$aEmbun, Raul$$uUniversidad de Zaragoza
000168077 245__ $$aCausal Model of Survival After Pulmonary Metastasectomy of Colorectal Cancer: A Nationwide Prospective Registry
000168077 260__ $$c2016
000168077 5203_ $$aBackground
Although numerous existing studies have analyzed the prognostic factors of patients who have had surgical intervention for lung metastases of colorectal carcinoma (CRC), many of the results obtained until now have been contradictory. As a consequence, there is no established consensus about which group of prognostic factors could have a greater value when considered together.
Methods
This was a multicenter prospective cohort study that included all patients who underwent a first pulmonary metastasectomy of CRC, with radical intent, during a 2-year period (March 2008 to February 2010). The follow-up continued until March 2013, and an analysis of disease-specific survival (DSS), determined from the first pulmonary metastasectomy, was implemented. The selection of the best submodel was taken based on their coefficient of determination (R2) and how parsimonious they were depending on the number of variables included.
Results
The series, consisting of 522 patients, presented the following survival rates: median, 54.9 months; 3-year DSS, 69.4% (95% confidence interval [CI], 65% to 73.8%); and 5-year DSS, 46.1% (95% CI, 38.5% to 53.7%). The resulting survival model consisted of disease-free interval of 12 months or less (hazard ratio [HR], 1.76; 95% CI, 1.21 to 2.54; p = 0.003), carcinoembryonic antigen level exceeding 5 ng/mL (HR, 1.50; 95% CI, 1.04 to 2.17; p = 0.028), bilateral lung disease (HR, 1.81; 95% CI, 1.20 to 2.75; p = 0.005), and thoracic lymph node involvement (HR, 2.71; 95% CI, 1.44 to 5.12; p = 0.002).
Conclusions
According to these results from the Spanish Group of Lung Metastases of Colo-Rectal Cancer, the combination of these four variables—disease-free interval, carcinoembryonic antigen level, laterality, and thoracic lymph node involvement—constitutes the first-choice survival causal model based on the clinical and pathologic factors most frequently referenced in literature.
000168077 540__ $$9info:eu-repo/semantics/closedAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000168077 590__ $$a3.7$$b2016
000168077 591__ $$aSURGERY$$b27 / 195 = 0.138$$c2016$$dQ1$$eT1
000168077 591__ $$aCARDIAC & CARDIOVASCULAR SYSTEMS$$b41 / 126 = 0.325$$c2016$$dQ2$$eT1
000168077 591__ $$aRESPIRATORY SYSTEM$$b17 / 59 = 0.288$$c2016$$dQ2$$eT1
000168077 592__ $$a1.41$$b2016
000168077 593__ $$aCardiology and Cardiovascular Medicine$$c2016$$dQ1
000168077 593__ $$aSurgery$$c2016$$dQ1
000168077 593__ $$aPulmonary and Respiratory Medicine$$c2016$$dQ1
000168077 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000168077 700__ $$aRivas de Andrés, Juan J.$$uUniversidad de Zaragoza
000168077 700__ $$aCall, Sergi
000168077 700__ $$ade Olaiz Navarro, Beatriz
000168077 700__ $$aFreixinet, Jorge L.
000168077 700__ $$aBolufer, Sergio
000168077 700__ $$aJarabo, Jose R.
000168077 700__ $$aPajuelo, Nuria
000168077 700__ $$aMolins, Laureano
000168077 700__ $$aSpanish Society of Pneumology and Thoracic Surgery (SEPAR)
000168077 7102_ $$11004$$2090$$aUniversidad de Zaragoza$$bDpto. Cirugía,Ginecol.Obstetr.$$cÁrea Cirugía
000168077 773__ $$g101, 5 (2016), 1883-1890$$pAnn. thorac. surg.$$tANNALS OF THORACIC SURGERY$$x0003-4975
000168077 8564_ $$s700994$$uhttps://zaguan.unizar.es/record/168077/files/texto_completo.pdf$$yVersión publicada
000168077 8564_ $$s3086358$$uhttps://zaguan.unizar.es/record/168077/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000168077 909CO $$ooai:zaguan.unizar.es:168077$$particulos$$pdriver
000168077 951__ $$a2026-01-26-14:49:56
000168077 980__ $$aARTICLE