000168202 001__ 168202
000168202 005__ 20260128162436.0
000168202 0247_ $$2doi$$a10.1016/j.jelectrocard.2013.03.001
000168202 0248_ $$2sideral$$a83070
000168202 037__ $$aART-2013-83070
000168202 041__ $$aeng
000168202 100__ $$aDemidova, M.
000168202 245__ $$aT wave alternans in experimental myocardial infarction: Time course and predictive value for the assessment of myocardial damage
000168202 260__ $$c2013
000168202 5060_ $$aAccess copy available to the general public$$fUnrestricted
000168202 5203_ $$aBackground
T-wave alternans (TWA) is associated with prognosis after myocardial infarction (MI), however its link to the extent of ischemic injury has not been clarified. We analyzed the course of TWA and its relation to myocardial damage in experimental myocardial infarction.
Methods
In 21 pigs, infarction was induced by 40-minute long balloon inflation in LAD under continuous 12-lead ECG monitoring. TWA was assessed in a 32-beat sliding window, using periodic component analysis and the Laplacian Likelihood Ratio method. Myocardium at risk (MaR) and infarct size (IS) were evaluated by SPECT and magnetic resonance imaging respectively.
Results
TWA appeared at 7.2 ± 4.5 minutes of occlusion, reached its maximum at 12.7 ± 6.3 and lasted until 26.5 ± 9.2 minutes. The maximal level of TWA was associated with both MaR (r = 0.499, p = 0.035) and IS (r = 0.65, p = 0.004).
Conclusion
TWA magnitude is associated with both MaR and IS in experiment, which encourages further studies in clinical settings.
000168202 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
000168202 590__ $$a1.363$$b2013
000168202 591__ $$aCARDIAC & CARDIOVASCULAR SYSTEMS$$b84 / 125 = 0.672$$c2013$$dQ3$$eT3
000168202 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000168202 700__ $$0(orcid)0000-0003-0226-4950$$aMartín-Yebra, A.
000168202 700__ $$0(orcid)0000-0002-7503-3339$$aMartínez, J.P.$$uUniversidad de Zaragoza
000168202 700__ $$0(orcid)0000-0001-5343-5671$$aMonasterio, V.$$uUniversidad de Zaragoza
000168202 700__ $$aKoul, S.
000168202 700__ $$avan der Pals, J
000168202 700__ $$0(orcid)0000-0001-5269-9667$$aRomero, D.
000168202 700__ $$0(orcid)0000-0003-3434-9254$$aLaguna, P.$$uUniversidad de Zaragoza
000168202 700__ $$aErlinge, D.
000168202 700__ $$aPlatonov, P.G.
000168202 7102_ $$15007$$2520$$aUniversidad de Zaragoza$$bDpto. Informát.Ingenie.Sistms.$$cÁrea Ingen.Sistemas y Automát.
000168202 7102_ $$15008$$2800$$aUniversidad de Zaragoza$$bDpto. Ingeniería Electrón.Com.$$cÁrea Teoría Señal y Comunicac.
000168202 773__ $$g46, 3 (2013), 263-269$$pJ. electrocardiol.$$tJOURNAL OF ELECTROCARDIOLOGY$$x0022-0736
000168202 8564_ $$s974984$$uhttps://zaguan.unizar.es/record/168202/files/texto_completo.pdf$$yPostprint
000168202 8564_ $$s2444556$$uhttps://zaguan.unizar.es/record/168202/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000168202 909CO $$ooai:zaguan.unizar.es:168202$$particulos$$pdriver
000168202 951__ $$a2026-01-28-15:37:44
000168202 980__ $$aARTICLE