168202 20260128162436.0 doi 10.1016/j.jelectrocard.2013.03.001 sideral 83070 ART-2013-83070 eng Demidova, M. T wave alternans in experimental myocardial infarction: Time course and predictive value for the assessment of myocardial damage 2013 Background T-wave alternans (TWA) is associated with prognosis after myocardial infarction (MI), however its link to the extent of ischemic injury has not been clarified. We analyzed the course of TWA and its relation to myocardial damage in experimental myocardial infarction. Methods In 21 pigs, infarction was induced by 40-minute long balloon inflation in LAD under continuous 12-lead ECG monitoring. TWA was assessed in a 32-beat sliding window, using periodic component analysis and the Laplacian Likelihood Ratio method. Myocardium at risk (MaR) and infarct size (IS) were evaluated by SPECT and magnetic resonance imaging respectively. Results TWA appeared at 7.2 ± 4.5 minutes of occlusion, reached its maximum at 12.7 ± 6.3 and lasted until 26.5 ± 9.2 minutes. The maximal level of TWA was associated with both MaR (r = 0.499, p = 0.035) and IS (r = 0.65, p = 0.004). Conclusion TWA magnitude is associated with both MaR and IS in experiment, which encourages further studies in clinical settings. Access copy available to the general public Unrestricted info:eu-repo/semantics/openAccess by-nc-nd https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es 1.363 2013 CARDIAC & CARDIOVASCULAR SYSTEMS 84 / 125 = 0.672 2013 Q3 T3 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Martín-Yebra, A. (orcid)0000-0003-0226-4950 Martínez, J.P. Universidad de Zaragoza (orcid)0000-0002-7503-3339 Monasterio, V. Universidad de Zaragoza (orcid)0000-0001-5343-5671 Koul, S. van der Pals, J Romero, D. (orcid)0000-0001-5269-9667 Laguna, P. Universidad de Zaragoza (orcid)0000-0003-3434-9254 Erlinge, D. Platonov, P.G. 5007 520 Universidad de Zaragoza Dpto. Informát.Ingenie.Sistms. Área Ingen.Sistemas y Automát. 5008 800 Universidad de Zaragoza Dpto. Ingeniería Electrón.Com. Área Teoría Señal y Comunicac. 46, 3 (2013), 263-269 J. electrocardiol. JOURNAL OF ELECTROCARDIOLOGY 0022-0736 974984 http://zaguan.unizar.es/record/168202/files/texto_completo.pdf Postprint 2444556 http://zaguan.unizar.es/record/168202/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:168202 articulos driver 2026-01-28-15:37:44 ARTICLE