000168204 001__ 168204
000168204 005__ 20260128162436.0
000168204 0247_ $$2doi$$a10.1016/j.hrthm.2014.03.048
000168204 0248_ $$2sideral$$a86590
000168204 037__ $$aART-2014-86590
000168204 041__ $$aeng
000168204 100__ $$aDemidova, M. M.
000168204 245__ $$aTransient and rapid QRS-widening associated with a J-wave pattern predicts impending ventricular fibrillation in experimental myocardial infarction
000168204 260__ $$c2014
000168204 5060_ $$aAccess copy available to the general public$$fUnrestricted
000168204 5203_ $$aBackground
Certain types of the early repolarization phenomenon, previously considered to be benign, have been reported to be associated with ventricular fibrillation (VF), both in population-based studies and in the myocardial infarction (MI) settings.
Objective
To analyze whether QRS widening and appearance of a J-wave pattern in experimental MI settings is predictive of VF.
Methods
MI was induced in 32 pigs by 40-minute inflation of an angioplasty balloon in the left descending artery, and electrocardiogram was continuously recorded. Multilead QRS boundaries were computed, and QRS duration was calculated on a beat-to-beat basis during the occlusion period for each pig. An association between QRS widening and subsequent VF was studied using receiver operating characteristic curve analysis. Electrocardiograms at maximum QRS duration were reviewed for the presence of a J-wave pattern.
Results
Sixteen animals had VF episodes during the occlusion period. Two peaks of QRS widening were found in all animals: the first peak immediately on left descending artery occlusion and the second peak 19.1 ± 4.0 minutes later. The magnitude of changes in the QRS width over time had significant interindividual differences. A QRS widening of ≥28 ms during a 3-minute time window was observed in 14 animals and predicted impending VF (selectivity 80%, specificity 73%, positive predictive value 57%, and negative predictive value 89%; P = .008). In 10 of 14 (71%) pigs, a J-wave pattern appeared at maximal QRS duration. The appearance of a J-wave pattern predicted VF with selectivity 80%, specificity 68%, positive predictive value 53%, and negative predictive value 88% (P = .02).
Conclusion
Transient QRS widening, commonly associated with a J-wave pattern, appears to predict impending VF in acute ischemia settings and motivates further clinical studies for monitoring immediate risk of VF in MI.
000168204 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
000168204 590__ $$a5.076$$b2014
000168204 591__ $$aCARDIAC & CARDIOVASCULAR SYSTEMS$$b18 / 123 = 0.146$$c2014$$dQ1$$eT1
000168204 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000168204 700__ $$0(orcid)0000-0003-0226-4950$$aMartín-Yebra, A.
000168204 700__ $$aVan, Der Pals
000168204 700__ $$aKoul, S.
000168204 700__ $$aErlinge, D.
000168204 700__ $$0(orcid)0000-0003-3434-9254$$aLaguna, P.$$uUniversidad de Zaragoza
000168204 700__ $$0(orcid)0000-0002-7503-3339$$aMartínez, J. P.$$uUniversidad de Zaragoza
000168204 700__ $$aPlatonov, P. G.
000168204 7102_ $$15008$$2800$$aUniversidad de Zaragoza$$bDpto. Ingeniería Electrón.Com.$$cÁrea Teoría Señal y Comunicac.
000168204 773__ $$g11, 7 (2014), 1195-1201$$pHeart Rhythm$$tHEART RHYTHM$$x1547-5271
000168204 8564_ $$s426116$$uhttps://zaguan.unizar.es/record/168204/files/texto_completo.pdf$$yPostprint
000168204 8564_ $$s930852$$uhttps://zaguan.unizar.es/record/168204/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000168204 909CO $$ooai:zaguan.unizar.es:168204$$particulos$$pdriver
000168204 951__ $$a2026-01-28-15:37:47
000168204 980__ $$aARTICLE