000168244 001__ 168244
000168244 005__ 20260130124311.0
000168244 0247_ $$2doi$$a10.3389/fcell.2022.924272
000168244 0248_ $$2sideral$$a129936
000168244 037__ $$aART-2022-129936
000168244 041__ $$aeng
000168244 100__ $$0(orcid)0000-0002-2469-142X$$aFernández-Vizarra, Erika
000168244 245__ $$aEditorial: Mitochondrial OXPHOS System: Emerging Concepts and Technologies and Role in Disease
000168244 260__ $$c2022
000168244 5060_ $$aAccess copy available to the general public$$fUnrestricted
000168244 5203_ $$aMitochondria are eukaryotic organelles responsible for generating the main bulk of ATP, the cellular energy currency, via the process of oxidative phosphorylation (OXPHOS). The OXPHOS system is unique because it comprises subunits of dual genetic origin, encoded in the mitochondrial and the nuclear genomes. Therefore, to form the multimeric membrane-bound complexes responsible for this energy production process, proteins translated inside the organelle must be assembled in coordination with those expressed in the cytosol and imported into mitochondria by using a sophisticated import and translocation machinery. The idea that the OXPHOS system plays a role not only in ATP production but also in regulating many physiological and pathological processes has been emerging for more than 10 years. Recent evidence points to the existence of intricate quality control systems that guarantee the functionality of mitochondria, as well as the interactions of intramitochondrial and extramitochondrial factors that ultimately influence mitochondrial bioenergetics. For these reasons this Research Topic is a timely release, covering emerging concepts relating to the structure, function, and regulation of the OXPHOS system. In addition, the Research Topic also presents novel technological approaches to unravel the yet unknown intricacies involving this group of protein complexes as well as new mechanisms or pathways linking OXPHOS dysfunction and pathological states.
000168244 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es
000168244 590__ $$a5.5$$b2022
000168244 591__ $$aDEVELOPMENTAL BIOLOGY$$b5 / 39 = 0.128$$c2022$$dQ1$$eT1
000168244 591__ $$aCELL BIOLOGY$$b66 / 191 = 0.346$$c2022$$dQ2$$eT2
000168244 592__ $$a1.418$$b2022
000168244 593__ $$aDevelopmental Biology$$c2022$$dQ1
000168244 593__ $$aCell Biology$$c2022$$dQ2
000168244 594__ $$a6.3$$b2022
000168244 655_4 $$ainfo:eu-repo/semantics/other$$vinfo:eu-repo/semantics/publishedVersion
000168244 700__ $$aCallegari, Sylvie
000168244 700__ $$aGarrabou, Gloria
000168244 700__ $$0(orcid)0000-0003-2645-3983$$aPacheu-Grau, David$$uUniversidad de Zaragoza
000168244 7102_ $$11002$$2060$$aUniversidad de Zaragoza$$bDpto. Bioq.Biolog.Mol. Celular$$cÁrea Bioquímica y Biolog.Mole.
000168244 773__ $$g10 (2022), 924272 [3 pp.]$$tFrontiers in Cell and Developmental Biology$$x2296-634X
000168244 8564_ $$s540789$$uhttps://zaguan.unizar.es/record/168244/files/texto_completo.pdf$$yVersión publicada
000168244 8564_ $$s2566918$$uhttps://zaguan.unizar.es/record/168244/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
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000168244 951__ $$a2026-01-30-12:20:35
000168244 980__ $$aARTICLE