Impact of an endurance training program on exercise-induced cardiac biomarker release

Legaz-Arrese, A. (Universidad de Zaragoza) ; López-Laval, I. ; George, K. ; Puente-Lanzarote, J. ; Mayolas-Pi, C. (Universidad de Zaragoza) ; Serrano-Ostáriz, E. (Universidad de Zaragoza) ; Revilla-Martí, P. ; Moliner-Urdiales, D. ; Reverter-Masià, J.

Resumen: We evaluated the influence of a 14-wk endurance running program on the exercise-induced release of high-sensitivity cardiac troponin T (hs-cTnT) and NH2-terminal pro-brain natriuretic peptide (NT-proBNP). Fifty-eight untrained participants were randomized to supervised endurance exercise (14 wk, 3–4 days/wk, 120–240 min/wk, 65–85% of maximum heart rate) or a control group. At baseline and after the training program, hs-cTnT and NT-proBNP were assessed before and 5 min, 1 h, 3 h, 6 h, 12 h, and 24 h after a 60-min maximal running test. Before training, hs-cTnT was significantly elevated in both groups with acute exercise (P < 0.0001) with no between-group differences. There was considerable heterogeneity in peak hs-cTnT concentration with the upper reference limit exceeded in 71% of the exercise tests. After training, both baseline and postexercise hs-cTnT were significantly higher compared with pretraining and the response of the control group (P = 0.008). Acute exercise led to a small but significant increase in NT-proBNP, but this was not mediated by training (P = 0.121). In summary, a controlled endurance training intervention resulted in higher pre- and postexercise values of hs-cTnT with no changes in NT-proBNP.

Idioma: Inglés

DOI: 10.1152/ajpheart.00914.2014

Año: 2015

Publicado en: AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 308, 8 (2015), H913-H920
ISSN: 0363-6135

Factor impacto JCR: 3.324 (2015)

Categ. JCR: CARDIAC & CARDIOVASCULAR SYSTEMS rank: 39 / 124 = 0.315 (2015) - Q2 - T1
Categ. JCR: PHYSIOLOGY rank: 21 / 83 = 0.253 (2015) - Q2 - T1
Categ. JCR: PERIPHERAL VASCULAR DISEASE rank: 17 / 63 = 0.27 (2015) - Q2 - T1

Factor impacto SCIMAGO: 1.883 - Cardiology and Cardiovascular Medicine (Q1) - Physiology (medical) (Q1) - Physiology (Q1)

Tipo y forma: Artículo (Versión definitiva)

Área (Departamento): Área Educación Física y Depor. (Dpto. Fisiatría y Enfermería)