doi:10.1152/ajpheart.00914.2014engLegaz-Arrese, A.López-Laval, I.George, K.Puente-Lanzarote, J.Mayolas-Pi, C.Serrano-Ostáriz, E.Revilla-Martí, P.Moliner-Urdiales, D.Reverter-Masià, J.Impact of an endurance training program on exercise-induced cardiac biomarker releaseART-2015-90413We evaluated the influence of a 14-wk endurance running program on the exercise-induced release of high-sensitivity cardiac troponin T (hs-cTnT) and NH2-terminal pro-brain natriuretic peptide (NT-proBNP). Fifty-eight untrained participants were randomized to supervised endurance exercise (14 wk, 3–4 days/wk, 120–240 min/wk, 65–85% of maximum heart rate) or a control group. At baseline and after the training program, hs-cTnT and NT-proBNP were assessed before and 5 min, 1 h, 3 h, 6 h, 12 h, and 24 h after a 60-min maximal running test. Before training, hs-cTnT was significantly elevated in both groups with acute exercise (P < 0.0001) with no between-group differences. There was considerable heterogeneity in peak hs-cTnT concentration with the upper reference limit exceeded in 71% of the exercise tests. After training, both baseline and postexercise hs-cTnT were significantly higher compared with pretraining and the response of the control group (P = 0.008). Acute exercise led to a small but significant increase in NT-proBNP, but this was not mediated by training (P = 0.121). In summary, a controlled endurance training intervention resulted in higher pre- and postexercise values of hs-cTnT with no changes in NT-proBNP.2015http://zaguan.unizar.es/record/16831210.1152/ajpheart.00914.2014http://zaguan.unizar.es/record/168312oai:zaguan.unizar.es:168312AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 308, 8 (2015), H913-H920All rights reservedhttp://www.europeana.eu/rights/rr-f/info:eu-repo/semantics/openAccess