168312 20260204153542.0 doi 10.1152/ajpheart.00914.2014 sideral 90413 ART-2015-90413 eng Legaz-Arrese, A. Universidad de Zaragoza (orcid)0000-0003-2644-9386 Impact of an endurance training program on exercise-induced cardiac biomarker release 2015 We evaluated the influence of a 14-wk endurance running program on the exercise-induced release of high-sensitivity cardiac troponin T (hs-cTnT) and NH2-terminal pro-brain natriuretic peptide (NT-proBNP). Fifty-eight untrained participants were randomized to supervised endurance exercise (14 wk, 3–4 days/wk, 120–240 min/wk, 65–85% of maximum heart rate) or a control group. At baseline and after the training program, hs-cTnT and NT-proBNP were assessed before and 5 min, 1 h, 3 h, 6 h, 12 h, and 24 h after a 60-min maximal running test. Before training, hs-cTnT was significantly elevated in both groups with acute exercise (P < 0.0001) with no between-group differences. There was considerable heterogeneity in peak hs-cTnT concentration with the upper reference limit exceeded in 71% of the exercise tests. After training, both baseline and postexercise hs-cTnT were significantly higher compared with pretraining and the response of the control group (P = 0.008). Acute exercise led to a small but significant increase in NT-proBNP, but this was not mediated by training (P = 0.121). In summary, a controlled endurance training intervention resulted in higher pre- and postexercise values of hs-cTnT with no changes in NT-proBNP. Access copy available to the general public Unrestricted info:eu-repo/semantics/openAccess All rights reserved http://www.europeana.eu/rights/rr-f/ 3.324 2015 CARDIAC & CARDIOVASCULAR SYSTEMS 39 / 124 = 0.315 2015 Q2 T1 PHYSIOLOGY 21 / 83 = 0.253 2015 Q2 T1 PERIPHERAL VASCULAR DISEASE 17 / 63 = 0.27 2015 Q2 T1 1.883 2015 Cardiology and Cardiovascular Medicine 2015 Q1 Physiology (medical) 2015 Q1 Physiology 2015 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion López-Laval, I. (orcid)0000-0002-9304-3709 George, K. Puente-Lanzarote, J. (orcid)0000-0002-7213-7095 Mayolas-Pi, C. Universidad de Zaragoza (orcid)0000-0003-0721-2447 Serrano-Ostáriz, E. Universidad de Zaragoza (orcid)0000-0002-8170-9403 Revilla-Martí, P. Moliner-Urdiales, D. Reverter-Masià, J. 1006 245 Universidad de Zaragoza Dpto. Fisiatría y Enfermería Área Educación Física y Depor. 308, 8 (2015), H913-H920 Am. j. physiol, Heart circ. physiol. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 0363-6135 805103 http://zaguan.unizar.es/record/168312/files/texto_completo.pdf Versión publicada 3953310 http://zaguan.unizar.es/record/168312/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:168312 articulos driver 2026-02-04-13:13:31 ARTICLE