000168324 001__ 168324
000168324 005__ 20260204153543.0
000168324 0247_ $$2doi$$a10.1016/j.hrthm.2020.07.037
000168324 0248_ $$2sideral$$a146831
000168324 037__ $$aART-2021-146831
000168324 041__ $$aeng
000168324 100__ $$aPenela D.
000168324 245__ $$aPremature ventricular complex site of origin and ablation outcomes in patients with prior myocardial infarction
000168324 260__ $$c2021
000168324 5060_ $$aAccess copy available to the general public$$fUnrestricted
000168324 5203_ $$aBackground
Frequent premature ventricular complexes (PVCs) are common after a myocardial infarction (MI), but data on PVC ablation in this population are limited.
Objective
The purpose of this study was to analyze data on PVC ablation in post-MI patients.
Methods
Three hundred thirty-two patients with frequent PVCs and left ventricular (LV) dysfunction were prospectively studied. Data from 67 patients (20%; age 63 ± 10 years; 65 men [93%]) with previous MI were compared with the remaining 265 patients.
Results
PVCs in post-MI patients originate predominantly from the LV (92% LV vs 6% right ventricle [RV]; P <.001). The most frequent sites of origin (SOO) were MI scar in 23 patients (34%) and left ventricular outflow tract (LVOT) in 22 patients (33%). A papillary muscle origin was more frequent in post-MI patients (16% vs 4%; P = .001), whereas an RV outflow tract origin was less frequent (1% vs 33%; P <.001) compared to patients without MI. In post-MI patients, PVC burden decreased from 29% ± 12% at baseline to 4.6% ± 7% (P <.001); left ventricular ejection fraction (LVEF) improved from 33.6% ± 8% to 42% ± 10% (P <.001); and New York Heart Association functional class improved from 2.1 ± 0.7 to 1.4 ± 0.5 points (P <.001) at 12 months. Compared with the remaining 265 patients, there were no differences in acute ablation success (85% vs 85%; P = .45), complication rate (6% vs 6%; P = .41), or absolute improvement in LVEF (8.8 ± 10 vs 9.9 ± 11 absolute points; P = .38).
Conclusion
PVC ablation significantly improves cardiac function and functional status in post-MI patients. PVCs predominantly originate from MI scar and LVOT. A papillary muscle SOO was found to be strongly associated with previous MI.
000168324 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
000168324 590__ $$a6.779$$b2021
000168324 591__ $$aCARDIAC & CARDIOVASCULAR SYSTEMS$$b36 / 143 = 0.252$$c2021$$dQ2$$eT1
000168324 592__ $$a2.402$$b2021
000168324 593__ $$aPhysiology (medical)$$c2021$$dQ1
000168324 593__ $$aCardiology and Cardiovascular Medicine$$c2021$$dQ1
000168324 594__ $$a10.1$$b2021
000168324 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000168324 700__ $$aTeres C.
000168324 700__ $$aFernández-Armenta J.
000168324 700__ $$aAguinaga L.
000168324 700__ $$aTercedor L.
000168324 700__ $$aSoto-Iglesias D.
000168324 700__ $$0(orcid)0000-0001-9187-1773$$aJauregui, B.
000168324 700__ $$aOrdóñez A.
000168324 700__ $$aAcosta J.
000168324 700__ $$aBisbal F.
000168324 700__ $$aAceña M.
000168324 700__ $$aSilva E.
000168324 700__ $$aChauca A.
000168324 700__ $$aDe Sensi F.
000168324 700__ $$aVatasescu R.
000168324 700__ $$aSánchez-Millán P.
000168324 700__ $$aCarballo J.
000168324 700__ $$aMont L.
000168324 700__ $$aBerruezo A.
000168324 773__ $$g18, 1 (2021), 27 - 33$$pHeart Rhythm$$tHEART RHYTHM$$x1547-5271
000168324 8564_ $$s6134296$$uhttps://zaguan.unizar.es/record/168324/files/texto_completo.pdf$$yPostprint
000168324 8564_ $$s1648810$$uhttps://zaguan.unizar.es/record/168324/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000168324 909CO $$ooai:zaguan.unizar.es:168324$$particulos$$pdriver
000168324 951__ $$a2026-02-04-13:13:46
000168324 980__ $$aARTICLE