000168343 001__ 168343 000168343 005__ 20260204153543.0 000168343 0247_ $$2doi$$a10.3390/pharmaceutics18010039 000168343 0248_ $$2sideral$$a147830 000168343 037__ $$aART-2025-147830 000168343 041__ $$aeng 000168343 100__ $$aCebollada, Pilar 000168343 245__ $$aAntibacterial Activity of Palmarosa (Cymbopogon martini (Roxb.) Will.Watson) Essential Oil and Geraniol Against Clinical Isolates from Respiratory, Skin, and Soft Tissue Infections 000168343 260__ $$c2025 000168343 5060_ $$aAccess copy available to the general public$$fUnrestricted 000168343 5203_ $$aBackground/Objectives: Essential oils are liquid natural volatile mixture of compounds with several bioactive properties, which make them useful in a wide range of pharmaceutical applications. The aim of this work is to explore the antimicrobial impact of Cymbopogon martini essential oil against human clinical bacterial isolates from the skin and respiratory tract while also assessing its impact on mammalian cells. Geraniol, its main component according to GC-MS analysis, was evaluated under the same conditions. Methods: The composition of the essential oil was provided by the supplier. To elucidate the antimicrobial activity, the minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC) were determined. The impact on mammalian hepatic cells was determined using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Results: The essential oil showed activity against Gram-positive bacteria from the Streptococcus and Staphylococcus genera, with MIC values ranging from 125 to 250 µg mL−1 for Streptococcus agalactiae, Streptococcus anginosus, Streptococcus disgalactiae， and Streptococcus pyogenes. It also displayed activity against some of the tested Gram-negative bacteria, namely, Escherichia coli (MIC 350 µg mL−1), Moraxella catarrhalis (MIC 250 µg mL−1), and Morganella morganii (MIC 350 µg mL−1). In most cases, the essential oil showed lower MIC values than geraniol. Additionally, palmarosa oil had a weaker impact than geraniol in HepG2 cells. Conclusions: Both the essential oil and the pure compound exhibited activity against clinical isolates obtained from skin and respiratory tract samples. 000168343 536__ $$9info:eu-repo/grantAgreement/ES/DGA/B44-20R 000168343 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es 000168343 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000168343 700__ $$aAlvarado, Elena 000168343 700__ $$0(orcid)0000-0002-9742-1463$$aSeral, Cristina$$uUniversidad de Zaragoza 000168343 700__ $$0(orcid)0000-0001-6969-1055$$aLópez, Víctor 000168343 7102_ $$11011$$2630$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Microbiología 000168343 773__ $$g18, 1 (2025), 39 [11pp.]$$pPharmaceutics$$tPharmaceutics$$x1999-4923 000168343 8564_ $$s544541$$uhttps://zaguan.unizar.es/record/168343/files/texto_completo.pdf$$yVersión publicada 000168343 8564_ $$s2455832$$uhttps://zaguan.unizar.es/record/168343/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000168343 909CO $$ooai:zaguan.unizar.es:168343$$particulos$$pdriver 000168343 951__ $$a2026-02-04-13:14:09 000168343 980__ $$aARTICLE