000168356 001__ 168356
000168356 005__ 20260204153543.0
000168356 0247_ $$2doi$$a10.1111/jbg.70034
000168356 0248_ $$2sideral$$a147820
000168356 037__ $$aART-2025-147820
000168356 041__ $$aeng
000168356 100__ $$aMejuto-Vázquez, N.
000168356 245__ $$aGenomic Analysis of Inbreeding Depression on Productive Traits in Rubia Galega Beef Cattle Breed
000168356 260__ $$c2025
000168356 5060_ $$aAccess copy available to the general public$$fUnrestricted
000168356 5203_ $$aIn autochthonous livestock breeds with small populations, such as the Rubia Galega from Galicia (Spain), mating between relatives is common and can lead to inbreeding depression. Genomic inbreeding coefficients were estimated for 4984 animals using ~63,000 SNPs to assess inbreeding depression in four key traits: age at first calving (AFC) with 3503 records, calving interval (CI) with 3315 records, birth weight (BW) with 4878 records and weight at 210 days (W210) with 3285 records. Runs of homozygosity were sorted by length ([1,2], (2,4], (4,8], (8,16], > 16 Mb), and the corresponding inbreeding coefficients (FROH>1, FROH>2, FROH>4, FROH>8, FROH>16) were calculated using the consecutiveRUNs R package. A Genomic BLUP (GBLUP) was conducted for each FROH estimate using the BLUPF90+ programs. The results revealed significant inbreeding depression for AFC and CI, whereas W210 and BW exhibited similar inbreeding trends, but the effects of inbreeding on these traits were not statistically significant. To further explore the genetic basis of inbreeding depression, SNPs located within ROHs were tested, though a t-test, for their association with phenotypic traits. Genes located in significant regions (−log(p-value) > 3 from t-test) were annotated using Ensembl BioMart within a ± 0.5 Mb window. Recent inbreeding (ROH > 8 Mb) showed significant negative effects on reproductive traits, and key genomic regions—particularly on chromosome 2 involving MSTN, NAB1, and COL5A2—were linked to increased AFC and reduced BW and W210; ROH-based inbreeding estimates proved effective in detecting inbreeding depression in this native breed. Overall, ROH-based analyses revealed genomic regions and candidate genes, notably MSTN, contributing to inbreeding depression and key production traits in Rubia Galega cattle
000168356 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es
000168356 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000168356 700__ $$aHervás-Rivero, C.
000168356 700__ $$aRodríguez-Bermúdez, R.
000168356 700__ $$aLópez-Carbonell, D.$$uUniversidad de Zaragoza
000168356 700__ $$aHermida, M.
000168356 700__ $$aMartínez, P.
000168356 700__ $$0(orcid)0000-0001-6256-5478$$aVarona, L.$$uUniversidad de Zaragoza
000168356 7102_ $$11001$$2420$$aUniversidad de Zaragoza$$bDpto. Anatom.,Embri.Genét.Ani.$$cÁrea Genética
000168356 773__ $$g(2025), [16 pp.]$$pJ. anim. breed. genet.$$tJOURNAL OF ANIMAL BREEDING AND GENETICS$$x0931-2668
000168356 8564_ $$s2735424$$uhttps://zaguan.unizar.es/record/168356/files/texto_completo.pdf$$yVersión publicada
000168356 8564_ $$s2351820$$uhttps://zaguan.unizar.es/record/168356/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000168356 909CO $$ooai:zaguan.unizar.es:168356$$particulos$$pdriver
000168356 951__ $$a2026-02-04-13:14:25
000168356 980__ $$aARTICLE