000168401 001__ 168401
000168401 005__ 20260204153544.0
000168401 0247_ $$2doi$$a10.1093/sleep/zsaf382
000168401 0248_ $$2sideral$$a147872
000168401 037__ $$aART-2025-147872
000168401 041__ $$aeng
000168401 100__ $$aEbrahimian, Serajeddin
000168401 245__ $$aHypoxemia and arousals modulate cardiac responses to respiratory events in obstructive sleep apnea
000168401 260__ $$c2025
000168401 5060_ $$aAccess copy available to the general public$$fUnrestricted
000168401 5203_ $$aStudy Objectives: Respiratory events during sleep induce immediate cardiac alterations, including increased RR intervals during events and decreased RR intervals after events. However, the extent to which related desaturations and arousals modulate these responses remains underexplored. We hypothesized that desaturations and arousals are the main contributors to respiratory event-related cardiac response, with greatest cardiac alterations expected when both are present. Methods: We analyzed RR, QT, and heart rate-corrected QT (QTc) intervals before, during, and after 4310 respiratory events from 129 obstructive sleep apnea patients. Mixed-effect statistical models were utilized to assess the influence of the presence and severity of desaturations and arousals on the cardiac electrical response to respiratory events. Results: There were no significant differences between pre- and post-respiratory event RR and QTc intervals in the absence of desaturation or arousal. Arousal (RR estimate = −23.9 ms; QTc estimate = 5.7 ms) or simultaneous desaturation and arousal (RR estimate = −32.8 ms; QTc estimate = 8.4 ms) modulated significantly (p < .05) mean RR and QTc intervals after respiratory events. Desaturation alone affected only RR intervals (estimate = −9.3 ms, p<.05). Greater desaturation depth (RR estimate = −0.09 ms; QTc estimate = 0.56 ms) and longer arousal duration (RR estimate = −3.52 ms; QTc estimate = 0.84 ms) were significant (p < .05) predictors of RR and QTc magnitude alterations after respiratory events. Conclusions: Not all respiratory events have the same effects on cardiac electrophysiology; they are associated with acute alterations after events if they cause desaturations and/or arousal, with longer arousal and deeper desaturations increasing the magnitude of cardiac responses.
000168401 536__ $$9info:eu-repo/grantAgreement/ES/DGA/T39-23R$$9info:eu-repo/grantAgreement/EC/H2020/965417/EU/Revolution of sleep diagnostics and personalized health care based on digital diagnostics and therapeutics with health data integration/SLEEP REVOLUTION$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 965417-SLEEP REVOLUTION$$9info:eu-repo/grantAgreement/ES/MICINN/PID2021-126734OB-C21$$9info:eu-repo/grantAgreement/EUR/MICINN/TED2021-131106B-I00
000168401 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es
000168401 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000168401 700__ $$aSillanmäki, Saara
000168401 700__ $$aRissanen, Marika
000168401 700__ $$aStaykov, Eric
000168401 700__ $$aKulkas, Antti
000168401 700__ $$aTöyräs, Juha
000168401 700__ $$0(orcid)0000-0003-1272-0550$$aBailón, Raquel$$uUniversidad de Zaragoza
000168401 700__ $$aGrote, Ludger
000168401 700__ $$aBonsignore, Maria R
000168401 700__ $$aBaumert, Mathias
000168401 700__ $$aSomers, Virend K
000168401 700__ $$aTerrill, Philip
000168401 700__ $$aLeppänen, Timo
000168401 700__ $$aKainulainen, Samu
000168401 7102_ $$15008$$2800$$aUniversidad de Zaragoza$$bDpto. Ingeniería Electrón.Com.$$cÁrea Teoría Señal y Comunicac.
000168401 773__ $$g(2025), [12 pp.]$$pSleep (N.Y. N.Y.)$$tSleep$$x0161-8105
000168401 8564_ $$s1923841$$uhttps://zaguan.unizar.es/record/168401/files/texto_completo.pdf$$yVersión publicada
000168401 8564_ $$s2353742$$uhttps://zaguan.unizar.es/record/168401/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000168401 909CO $$ooai:zaguan.unizar.es:168401$$particulos$$pdriver
000168401 951__ $$a2026-02-04-13:15:18
000168401 980__ $$aARTICLE