168438 20260205155159.0 doi 10.3390/sym18010143 sideral 147884 ART-2026-147884 eng Crespo-Quintanilla, Jesús Alberto Application of the Time-Averaged Entropy Generation Rate (TAEGR) to Transient Hemodynamic Analysis of the Human Aorta Using CFD–FSI 2026 This work focuses on the development of a patient-specific transient CFD–FSI numerical model combined with the Time-Averaged Entropy Generation Rate (TAEGR) to predict hemodynamic parameters in the thoracic aorta, including the Oscillatory Shear Index (OSI) and the Time-Averaged Wall Shear Stress (TAWSS). While arterial blood flow can be modeled assuming either rigid or elastic arterial walls, the effect of wall compliance on these parameters, particularly on TAEGR, remains insufficiently characterized. Moreover, the interpretation of established indicators is not unique, as regions of vascular relevance may correspond to either high or low values of OSI and TAWSS. The proposed approach aims to identify symmetry and asymmetry in shear stress and entropy generation within the arterial wall, which are closely associated with the development of atherosclerotic plaque. Four aortas from clinical patients were analyzed using the proposed numerical framework to investigate blood flow behavior. The results revealed regions with high values of the hemodynamic parameters (OSI > 0.15, TAWSS ≥ 2 Pa, and TAEGR ≥ 20 W/m3K) predominantly located in the vicinity of the upper arterial branches. These regions, referred to as critical zones, are considered prone to the development of cardiovascular diseases, particularly atherosclerosis. The proposed numerical model provides a reliable qualitative framework for assessing symmetry and asymmetry in aortic blood flow patterns under different surgical conditions. Access copy available to the general public Unrestricted info:eu-repo/semantics/openAccess by https://creativecommons.org/licenses/by/4.0/deed.es info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Alfaro-Ayala, Jorge Arturo Ramírez-Minguela, José de Jesús Vidal-Lesso, Agustín Rodríguez-Alejandro, David Aarón López-Núñez, Oscar Alejandro Malvé, Mauro Martínez Barca, Miguel Ángel Universidad de Zaragoza (orcid)0000-0002-8375-0354 5004 605 Universidad de Zaragoza Dpto. Ingeniería Mecánica Área Mec.Med.Cont. y Teor.Est. 18, 143 (2026), 20 Symmetry (Basel) Symmetry 2073-8994 7456402 http://zaguan.unizar.es/record/168438/files/texto_completo.pdf Versión publicada 2377479 http://zaguan.unizar.es/record/168438/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:168438 articulos driver 2026-02-05-14:36:35 ARTICLE