168450 20260205155159.0 doi 10.3389/fphar.2025.1721689 sideral 147894 ART-2025-147894 eng Llor, Carl Antibiotic use for respiratory tract infections in nursing homes: a multicentre cross-sectional study 2025 Introduction: To evaluate the use of antibiotic treatment for respiratory tract infections (RTIs) in nursing homes in Spain, assess whether they were indicated based on current guidelines, and identify predictors of both use and inappropriate use of antibiotics. Methods: Cross-sectional study carried out in 34 nursing homes in five areas in Spain. Nursing staff self-registered residents related to antibiotic use for RTIs in February-April 2023. Nursing staff recorded data on residents with RTIs, including demographics, symptoms, diagnoses, and antibiotic use. Logistic regression models were applied to identify predictors of antibiotic prescription and inappropriate use based on clinical guidelines. Results: Among 533 recorded RTI cases, the most common diagnoses were common cold (19.7%) and acute bronchitis (18.8%). Antibiotics were prescribed in 77.5% of cases, mainly for otitis media, tonsillitis, and pneumonia, with amoxicillin-clavulanate being the most frequent (34%). Of 328 prescriptions assessed, 63.1% were deemed unnecessary. Factors strongly associated with antibiotic use included confusion (odds ratio 4.72; p = 0.005), perceived demand for antibiotics (OR 3.83; p < 0.001), and fever (OR 3.27; p = 0.005), whereas rhinorrhea reduced the likelihood of prescription (OR 0.23; p < 0.001). Discussion: The findings reveal substantial overuse of antibiotics for RTIs in nursing homes and highlight the need for targeted interventions to promote guideline-based prescribing and reduce inappropriate use. Access copy available to the general public Unrestricted info:eu-repo/semantics/openAccess by https://creativecommons.org/licenses/by/4.0/deed.es info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Morros, Rosa Mateos-Nozal, Jesús Zárate Sáez, Carlota Manuela Vaquero Pinto, María N. Rodríguez Jiménez, Consuelo Sáez Bejar, Carmen Magallón-Botaya, Rosa Universidad de Zaragoza (orcid)0000-0002-5494-6550 Matovelle, Priscila Navarro Sanmartín, Alicia López Pérez, Elena García-Sangenís, Ana Monfà, Ramon 1007 610 Universidad de Zaragoza Dpto. Medicina, Psiqu. y Derm. Area Medicina 16 (2025), [11 pp.] Front. pharmacol. Frontiers in Pharmacology 1663-9812 2401349 http://zaguan.unizar.es/record/168450/files/texto_completo.pdf Versión publicada 2206034 http://zaguan.unizar.es/record/168450/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:168450 articulos driver 2026-02-05-14:36:50 ARTICLE