000168530 001__ 168530
000168530 005__ 20260209162330.0
000168530 0247_ $$2doi$$a10.1016/j.psyneuen.2025.107718
000168530 0248_ $$2sideral$$a147943
000168530 037__ $$aART-2026-147943
000168530 041__ $$aeng
000168530 100__ $$aVallejo, Lorena
000168530 245__ $$aDiurnal cortisol cycle and cognitive performance in older people with Type 2 diabetes
000168530 260__ $$c2026
000168530 5060_ $$aAccess copy available to the general public$$fUnrestricted
000168530 5203_ $$aIn older adults with Type 2 Diabetes (T2D), hypothalamic-pituitary-adrenal (HPA) axis dysregulation accompanied by cognitive impairment has been reported. While the impact of HPA function on declarative memory (DM), working memory (WM), and executive function (EF) has received increased attention in aging research, its role in T2D remains largely unexplored. This study compared diurnal cortisol patterns and cognitive performance between 51 patients with T2D treated with oral antidiabetic medications, injectable therapies, or a combination of both, and 51 healthy controls matched for age, sex, educational level and, body mass index. Participants completed a battery of neuropsychological tests and the Beck Depression Inventory (BDI-II). Additionally, they provided four saliva samples per day across two weekdays to assess the cortisol awakening response (CAR) and the diurnal cortisol slope (DCS). Group comparisons (T2D vs. controls) and moderation analyses were conducted
to assess group differences and the associations between cortisol indices and cognitive performance, with group or depression included as moderators. T2D patients showed poorer performance than healthy controls, particularly on DM and WM, but no significant differences in CAR or DCS. In controls, a higher CAR was related to lower Stroop interference, although no significant relationships were found in T2D patients. Across the entire sample, CAR was negatively associated with Stroop interference at low and moderate depression levels, while DCS was positively associated with RAVLT delayed recall at low levels of depression. Our results indicate that medically treated T2D patients show poorer cognitive performance than healthy controls; however, cortisol does not seem to contribute to these cognitive deficits. These findings add to the limited literature on the impact of the HPA on cognitive function in T2D older adults, and they encourage future studies to delve into the mechanisms that could influence cognitive performance in this population, as well the relevance of depression in these cognitive deficits.
000168530 536__ $$9info:eu-repo/grantAgreement/ES/AEI/RED2022-134191-T$$9info:eu-repo/grantAgreement/ES/DGA/S31-23R$$9info:eu-repo/grantAgreement/ES/MICINN/PID2020-119406GB-I00
000168530 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es
000168530 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000168530 700__ $$aZapater-Fajarí, Mariola
000168530 700__ $$aMontoliu, Teresa
000168530 700__ $$0(orcid)0000-0003-3920-1099$$aHidalgo, Vanesa$$uUniversidad de Zaragoza
000168530 700__ $$aSalvador, Alicia
000168530 7102_ $$14009$$2725$$aUniversidad de Zaragoza$$bDpto. Psicología y Sociología$$cÁrea Psicobiología
000168530 773__ $$g185 (2026), 107718 [11 pp.]$$pPsychoneuroendocrinology$$tPSYCHONEUROENDOCRINOLOGY$$x0306-4530
000168530 8564_ $$s1483260$$uhttps://zaguan.unizar.es/record/168530/files/texto_completo.pdf$$yVersión publicada
000168530 8564_ $$s2374184$$uhttps://zaguan.unizar.es/record/168530/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000168530 909CO $$ooai:zaguan.unizar.es:168530$$particulos$$pdriver
000168530 951__ $$a2026-02-09-14:42:50
000168530 980__ $$aARTICLE