000168556 001__ 168556 000168556 005__ 20260211123807.0 000168556 0247_ $$2doi$$a10.1007/BF03165969 000168556 0248_ $$2sideral$$a101761 000168556 037__ $$aART-2009-101761 000168556 041__ $$aeng 000168556 100__ $$0(orcid)0000-0003-2005-8229$$aGonzález-Gil, E. M.$$uUniversidad de Zaragoza 000168556 245__ $$aSerum transaminases concentrations in obese children and adolescents 000168556 260__ $$c2009 000168556 5060_ $$aAccess copy available to the general public$$fUnrestricted 000168556 5203_ $$aThe aim of the study was to investigate the relationship between liver transaminase levels and metabolic syndrome (MS) features in obese children and adolescents. A total of 132 children and adolescents (73 males and 59 females) aged 8 - 16, participated in the study. All were studied at the department of Paediatrics, University Hospital of Zaragoza (Spain). Inclusion criteria were the existence of obesity as defined by body mass index (BMI) according to Cole cut-off values (when BMI was higher than the age and sex specific equivalent to 30 kg/m2). The definition of metabolic syndrome was according to the International Diabetes Federation criteria. Weight (kg), height (cm), waist circumference (cm), blood pressure and BMI were measured. Laboratory determinations after overnight fasting included: transaminases (ALT, AST, GGT), fasting glucose, insulin, triglycerides and HDL-C. The MS was found in 21.6% of the obese children and adolescents and the prevalence was higher in males (25.9%) than in females (15.9%). Serum transaminases (ALT, AST and GGT) mean concentrations were higher in males than in females, and decreased during pubertal development. The obese children and adolescents with the MS did not show higher transaminases concentrations when compared with those without the MS. Some MS manifestations (mainly waist circumference) showed a correlation with ALT, although all transaminases values were normal according to adult references. Liver transaminases, a surrogate marker of NAFLD, did not show an early and consistent manifestation of abnormalities in the obese children and adolescents studied. In order to define the presence of the disease, it would be necessary to obtain aminotransferase reference standards for children and adolescents, considering pubertal stage and gender. 000168556 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/ 000168556 590__ $$a0.891$$b2009 000168556 591__ $$aPHYSIOLOGY$$b66 / 75 = 0.88$$c2009$$dQ4$$eT3 000168556 591__ $$aBIOCHEMISTRY & MOLECULAR BIOLOGY$$b250 / 281 = 0.89$$c2009$$dQ4$$eT3 000168556 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion 000168556 700__ $$0(orcid)0000-0002-0902-387X$$aBueno Lozano, María Gloria$$uUniversidad de Zaragoza 000168556 700__ $$0(orcid)0000-0002-4888-7726$$aBueno Lozano, Olga$$uUniversidad de Zaragoza 000168556 700__ $$0(orcid)0000-0003-0454-653X$$aMoreno Aznar, Luis Alberto$$uUniversidad de Zaragoza 000168556 700__ $$aCuadrón Andrés, L. 000168556 700__ $$aHuerta Blas, P. 000168556 700__ $$0(orcid)0000-0002-5165-9716$$aGaragorri Otero, Jesús M.$$uUniversidad de Zaragoza 000168556 700__ $$0(orcid)0000-0002-6166-3612$$aBueno Lozano, Manuel$$uUniversidad de Zaragoza 000168556 7102_ $$11006$$2255$$aUniversidad de Zaragoza$$bDpto. Fisiatría y Enfermería$$cÁrea Enfermería 000168556 7102_ $$11006$$2X$$aUniversidad de Zaragoza$$bDpto. Fisiatría y Enfermería$$cProy. investigación DZA 000168556 7102_ $$11010$$2670$$aUniversidad de Zaragoza$$bDpto. Pediatría Radiol.Med.Fís$$cÁrea Pediatría 000168556 773__ $$g65, 1 (2009), 51-60$$pJ. physiol. biochem.$$tJournal of Physiology and Biochemistry$$x1138-7548 000168556 8564_ $$s322155$$uhttps://zaguan.unizar.es/record/168556/files/texto_completo.pdf$$yPostprint 000168556 8564_ $$s678836$$uhttps://zaguan.unizar.es/record/168556/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint 000168556 909CO $$ooai:zaguan.unizar.es:168556$$particulos$$pdriver 000168556 951__ $$a2026-02-11-10:27:05 000168556 980__ $$aARTICLE