168556 20260211123807.0 doi 10.1007/BF03165969 sideral 101761 ART-2009-101761 eng González-Gil, E. M. Universidad de Zaragoza (orcid)0000-0003-2005-8229 Serum transaminases concentrations in obese children and adolescents 2009 The aim of the study was to investigate the relationship between liver transaminase levels and metabolic syndrome (MS) features in obese children and adolescents. A total of 132 children and adolescents (73 males and 59 females) aged 8 - 16, participated in the study. All were studied at the department of Paediatrics, University Hospital of Zaragoza (Spain). Inclusion criteria were the existence of obesity as defined by body mass index (BMI) according to Cole cut-off values (when BMI was higher than the age and sex specific equivalent to 30 kg/m2). The definition of metabolic syndrome was according to the International Diabetes Federation criteria. Weight (kg), height (cm), waist circumference (cm), blood pressure and BMI were measured. Laboratory determinations after overnight fasting included: transaminases (ALT, AST, GGT), fasting glucose, insulin, triglycerides and HDL-C. The MS was found in 21.6% of the obese children and adolescents and the prevalence was higher in males (25.9%) than in females (15.9%). Serum transaminases (ALT, AST and GGT) mean concentrations were higher in males than in females, and decreased during pubertal development. The obese children and adolescents with the MS did not show higher transaminases concentrations when compared with those without the MS. Some MS manifestations (mainly waist circumference) showed a correlation with ALT, although all transaminases values were normal according to adult references. Liver transaminases, a surrogate marker of NAFLD, did not show an early and consistent manifestation of abnormalities in the obese children and adolescents studied. In order to define the presence of the disease, it would be necessary to obtain aminotransferase reference standards for children and adolescents, considering pubertal stage and gender. Access copy available to the general public Unrestricted info:eu-repo/semantics/openAccess All rights reserved http://www.europeana.eu/rights/rr-f/ 0.891 2009 PHYSIOLOGY 66 / 75 = 0.88 2009 Q4 T3 BIOCHEMISTRY & MOLECULAR BIOLOGY 250 / 281 = 0.89 2009 Q4 T3 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Bueno Lozano, María Gloria Universidad de Zaragoza (orcid)0000-0002-0902-387X Bueno Lozano, Olga Universidad de Zaragoza (orcid)0000-0002-4888-7726 Moreno Aznar, Luis Alberto Universidad de Zaragoza (orcid)0000-0003-0454-653X Cuadrón Andrés, L. Huerta Blas, P. Garagorri Otero, Jesús M. Universidad de Zaragoza (orcid)0000-0002-5165-9716 Bueno Lozano, Manuel Universidad de Zaragoza (orcid)0000-0002-6166-3612 1006 255 Universidad de Zaragoza Dpto. Fisiatría y Enfermería Área Enfermería 1006 X Universidad de Zaragoza Dpto. Fisiatría y Enfermería Proy. investigación DZA 1010 670 Universidad de Zaragoza Dpto. Pediatría Radiol.Med.Fís Área Pediatría 65, 1 (2009), 51-60 J. physiol. biochem. Journal of Physiology and Biochemistry 1138-7548 322155 http://zaguan.unizar.es/record/168556/files/texto_completo.pdf Postprint 678836 http://zaguan.unizar.es/record/168556/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:168556 articulos driver 2026-02-11-10:27:05 ARTICLE